Does Ozempic Make You Tired?

The man is yawning

If you’re considering taking Ozempic for weight loss or to manage type 2 diabetes, you may have questions about its potential side effects. One common concern is whether Ozempic can make you feel tired. Is it actually the case? Let’s explore the connection between Ozempic and fatigue, as well as provide tips on how to manage fatigue and improve your energy levels while taking Ozempic.

What Is Ozempic and How Does It Work?

Ozempic is the brand name for semaglutide, a medication used to treat type 2 diabetes. It belongs to the class of drugs known as glucagon-like peptide-1 (GLP-1) receptor agonists. Here’s how Ozempic works:

  • It mimics GLP-1 – Ozempic mimics the action of GLP-1, a naturally occurring hormone in the body. GLP-1 is released in response to food intake and plays a crucial role in regulating blood sugar levels.
  • It helps with insulin secretion – One of the primary effects of Ozempic is to stimulate the release of insulin from the pancreas. Insulin is a hormone that helps cells take up glucose from the bloodstream, lowering blood sugar levels.
  • It reduces glucagon production – Ozempic also reduces the production of glucagon, another hormone produced by the pancreas. Glucagon normally increases blood sugar levels by promoting the release of glucose from the liver.
  • It slows down gastric emptying – Ozempic slows down the rate at which the stomach empties its contents into the small intestine. This effect helps to regulate the absorption of glucose from the gut, preventing rapid spikes in blood sugar levels after meals.
  • It helps regulate the appetite – GLP-1, and consequently Ozempic, can influence appetite and satiety. Some people may experience a reduction in appetite, which can contribute to weight loss in individuals with type 2 diabetes.

By combining these mechanisms of action, Ozempic helps to control blood sugar levels in individuals with type 2 diabetes. It is typically administered as a subcutaneous injection, usually once a week. The medication is intended for use in conjunction with diet and exercise to improve glycemic control in adults with type 2 diabetes. It’s important to note that Ozempic is not approved for use in type 1 diabetes. As with any medication, it’s crucial to follow the prescribed dosage and recommendations of your healthcare provider.


Side Effects of Ozempic

The side effects of Ozempic are generally minor. While some people may experience fatigue or tiredness while taking Ozempic, this is a rare occurrence that typically resolves over time. The more common side effect is digestive upset, such as nausea, vomiting, diarrhea, abdominal pain, constipation, and bloating. However, these symptoms usually improve as your body adjusts to the medication.

Ozempic Fatigue – Can Ozempic Make You Tired?

So, does Ozempic cause fatigue? The short answer is that it can, but it’s not a common side effect. In clinical studies, only a small percentage of participants (0.4% or more) reported experiencing dizziness, fatigue, or tiredness while taking Ozempic. The exact reason why some people feel tired while others don’t is still unclear. However, it’s possible that the fatigue is related to how Ozempic works in the body.


Ozempic belongs to a class of medications called GLP-1 receptor agonists. These drugs work by controlling blood sugar levels and curbing appetite. They slow down digestion, reduce appetite, and increase the release of insulin in the body. These actions help stabilize blood sugar levels and decrease food intake. However, for some individuals, the effect of Ozempic on blood sugar and appetite may result in slightly lower blood sugar levels than they are used to. Low blood sugar can cause temporary lethargy and fatigue as the body adjusts to the medication. Additionally, a significant decrease in appetite may also contribute to feelings of tiredness.


It’s important to note that the majority of people who take Ozempic do not experience fatigue or a decrease in energy levels. Unless you experience hypoglycemia (low blood sugar), which is a rare but potentially serious side effect, it is unlikely that you will feel tired as a result of taking Ozempic. 

How to Manage Fatigue While Taking Ozempic?

If you do experience fatigue while taking Ozempic, there are several strategies you can try to improve your energy levels:

Improve sleep quality

Getting enough quality sleep is essential for maintaining overall health and reducing fatigue. Establishing a consistent bedtime routine, removing screens from the bedroom, keeping the bedroom dark, using white noise, and avoiding large meals, caffeine, and alcohol before bedtime can all contribute to better sleep quality. Prioritizing good sleep hygiene can help reduce fatigue and improve overall well-being.

Focus on nutrition

Proper nutrition plays a vital role in providing the body with the energy it needs to function optimally. Including lean proteins, whole grains, and high-quality fats in your diet can provide essential nutrients and support overall energy levels. 


The Mediterranean diet, which emphasizes these types of foods, has been associated with improved sleep quality. It’s important to note that while nutritional supplements can be beneficial, they should not replace a healthy diet. 


Additionally, staying hydrated by drinking enough water is crucial for supporting cellular function and energy metabolism.

Engage in regular exercise

Although exercise may seem counterintuitive when experiencing fatigue, research has shown that regular physical activity can actually reduce fatigue and increase overall energy levels. 

Exercise improves blood circulation, increases oxygen supply to the brain and organs, and stimulates the production of ATP, the body’s main source of energy. Engaging in activities that you enjoy, such as walking, swimming, or cycling, can help boost your energy levels and improve your overall well-being.

Prioritize mental health

Mental and emotional well-being play a significant role in energy levels and overall physical wellness. Fatigue is often a symptom of depression and other mental health conditions. Taking proactive steps to care for your mental health can help combat fatigue and improve your overall energy levels. This can include engaging in self-care activities, seeking support from a therapist, practicing stress management techniques, and maintaining social connections.

The Bottom Line

While fatigue is a rare side effect of taking Ozempic, it is not a common occurrence. The majority of individuals who take Ozempic do not experience fatigue or a decrease in energy levels. 

If you do experience fatigue, make sure to implement strategies outlined above that will help you manage tiredness and increase your energy levels. If you have any concerns about Ozempic and its side effects, don’t hesitate to reach out to us and we will help you with any questions you may have.


How does Ozempic work?

Ozempic works by mimicking the effects of GLP-1, a natural hormone that helps regulate blood sugar levels. It stimulates insulin secretion, reduces glucagon production, and slows down the absorption of glucose from the gut.

Common side effects may include nausea, vomiting, diarrhea, abdominal pain, and constipation. Some people may also experience injection site reactions.

Fatigue is listed as a possible side effect, but it doesn’t affect everyone. Different individuals may react differently to the medication, and some may not experience fatigue at all.

Fatigue can occur at any time while taking Ozempic. It may be more noticeable during the initial weeks of treatment or when the dosage is increased. However, it’s essential to inform your healthcare provider if fatigue persists or becomes severe.

It’s essential not to stop taking Ozempic without consulting your healthcare provider. They can evaluate your overall health and make appropriate adjustments to your treatment plan if needed.