What Happens When You Stop Taking Mounjaro

What Happens When You Stop Taking Mounjaro
Woman and man holding prescription medications

Mounjaro is an effective medication for managing blood sugar levels in individuals diagnosed with type 2 diabetes. Similar to drugs like Ozempic and Wegovy, it works to mimic the effect of hormones responsible for promoting insulin production and lowering blood sugar levels to safe parameters.

And just like these medications, Mounjaro also causes weight loss.

Patients who intend to stop taking the drug may have some concerns regarding how that change will affect them. This article will address these concerns.

Here is what happens when you stop taking Mounjaro.

Appetite Increase

Mounjaro, Ozempic or Wegovy work in a similar way, slowing down the whole digestive process. This has an impact on your appetite, as when you’re on the medication, you will likely feel less hungry, which helps introduce eating in moderation. This is one of the major ways in which drugs like Mounjaro contribute to weight loss.

It’s only natural that once you’re not administering Mounjaro, you will likely experience an appetite increase. 

Now, it’s important to remember that this is a shift you can prepare for. Medications like Mounjaro can be immensely helpful in achieving weight loss, but it’s also imperative to work on your relationship with food and cultivate healthy eating habits while you’re on them.

Working with a specialist to achieve this can be immensely beneficial, as you’re able to build a foundation for eating healthy for when your Mounjaro treatment ends and beyond. Consult your doctor and dietitian about how you can build lasting healthy eating habits. Use the help of an eating disorder therapist to address the root cause of your eating-related issues.

Weight Gain

If you relied heavily on Mounjaro in your weight loss journey and you haven’t acquired any other tools for managing your relationship with food, there is a risk of gaining weight after you stop the treatment.

How much you can gain is a very individualistic matter. You may gain a few pounds or gain back all the weight from before the treatment. A lot depends on your mental framework when getting off the medication and how well you are equipped to manage your eating habits without the assistance of the drug.

Again, we recommend that you work with a dietitian, therapist or eating disorder therapist throughout and after the Mounjaro treatment to increase the chance of maintaining your weight and building habits to manage it in a balanced and healthy manner.

a woman using a measuring tape measures herself at the waist

Blood Sugar Spikes

Patients with type 2 diabetes administer Mounjaro in order to keep their blood sugar level under control. The drug mimics the effect of GIP and GLP-1 hormones in the human body, which are responsible for exactly that – managing insulin secretion, glucose metabolism and regulating appetite.

Therefore, after getting off the medication, it’s possible to experience blood sugar level spikes. It’s crucial to stay in contact with your physician and manage this condition, as sudden and considerable blood sugar spikes are dangerous and can lead to a variety of other health risks.

Digestive Issues

Many common side effects of Mounjaro are gastrointestinal. The list of symptoms includes nausea, vomiting, constipation and diarrhea. While it is true that side effects pass after you stop taking the medication, it still might take a few days for that to happen.

Once you stop administering Mounjaro, your body may need some time to adjust to this change. During that time, there is a risk of experiencing symptoms like nausea, vomiting, diarrhea, and constipation.

Inform your doctor about these symptoms and adhere to their recommendations. 

How to Safely Stop Taking Mounjaro?

Stopping Mounjaro therapy abruptly can potentially lead to some complications. First of all, if you have type 2 diabetes, you should always talk about the medication switch and diabetes management with your physician. This is imperative to ensure your safety and health.

If you’re taking Mounjaro for weight loss, it’s also not a good idea to go off the drug without medical supervision and cold turkey. This increases the chance of experiencing withdrawal symptoms and side effects, which are fairly common when discontinuing using Mounjaro.

The best method of getting off the drug is doing so gradually, decreasing the doses over a longer period of time. 

Always consult your physician about discontinuing the Mounjaro treatment and adhere to their tapering plan.

For How Long Should You Take Mounjaro?

Mounjaro is usually prescribed as a long-term medication, meaning it can and should be administered until there is a clear need for it and it’s safe to do so. Of course, different aspects may influence the length of Mounjaro’s treatment. 

In all cases, it’s crucial to stay under medical supervision during the treatment. Based on your health history, current condition, treatment goals and other variables, your physician is able to determine what is the best course of action for you.  

Do Side Effects Pass After Getting Off Mounjaro?

Yes, Mounjaro side effects pass after you stop the treatment. However, it might take a few days for that to take place. There is also an increased risk of experiencing side effects when going cold turkey off the medication. 

If you’re experiencing side effects from Mounjaro, contact your doctor. You might be prescribed medications to alleviate some of the adverse symptoms.

When Should You Stop Taking Mounjaro?

There are some rare instances when discontinuing Mounjaro is a necessity. If you experience severe side effects, such as acute stomach pain, hypoglycemia (extremely low blood sugar), kidney dysfunction or allergic reaction, you should immediately stop administering the drug and receive medical intervention. 

Talk to your doctor beforehand about serious side effects and what you should look out for. 

What Happens When You Stop Taking Mounjaro – Conclusion

Getting off the Mounjaro is a process that is burdened with some risks and unpleasant side effects. That’s why it’s so important to go into it well-informed, prepared and under medical supervision. 

Staying in contact with your medical team will ensure the safest transition and offer you some valuable support in managing your condition as well as avoiding considerable weight gain.

If you’re an American citizen looking to buy Mounjaro at a much lower price, consider our pharmacy. Buy Mounjaro from Canada, save money and receive the medication you need in a matter of days. 

Refer to our How to Order Insulin from Canada guide, and contact us if you have more questions! 


  1. Endocrine, Metabolic & Immune Disorders-Drug Targets (Formerly Current Drug Targets – Immune, Endocrine & Metabolic Disorders), Tirzepatide: A New Generation Therapeutic for Diabetes Type 2
  2. Nourish, What Happens When You Stop Taking Mounjaro?
  3. Healthline, Here’s How Much Weight People Regain After Stopping Mounjaro, Zepbound
  4. Women’s Health, What Happens When You Stop Taking Mounjaro? Experts Explain What To Expect