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Humulin U-100 insulins were launched by Eli Lilly and Company in 1982 and have helped people with diabetes manage their diabetes for over 30 years.

Three types of Humulin U-100 insulin can treat diabetes and high blood sugar levels (glucose). The duration, peak timing, and onset of each type of insulin vary from one class to the next. It is critical to remember that insulin should only be used under the supervision and advice of a healthcare professional.

Humulin works continuously throughout the day to control blood sugar levels between meals, which is called basal insulin. According to your needs, Humulin injections can be given once daily or twice daily. Most commonly, injections are given before bedtime. You can, however, get them before the morning meal or the evening meal. Your Healthcare Professional will explain when you should take Humulin.

Humulin R U-100: What Is It?

Quick-acting insulin is used to lower blood sugar levels after eating food within 30 minutes.

Humulin R U-100 is short-acting, meaning it can cover insulin needs for meals consumed within 30 minutes.

Humulin R insulin is available in two forms: Humulin R U-100 and Humulin R U-500, a more concentrated insulin. The U-100 insulins include Humulin R and other products containing 100 units per mL. The right product must be chosen.

Humulin R U-100 is an injection that must be administered under the skin. A muscle injection is not recommended. A unit of insulin is equal to one unit of glucose. Using a syringe marked for Humulin R U-100 insulin is necessary when using Humulin R U-100.

Never use Humulin R U-100:

– if it appears cloudy, thickened, or slightly colored, or

– if it appears to contain solid particles

Discuss your insulin requirements with your doctor.

A pen or needle should be used only by one patient and should not be shared, even in healthcare facilities, as diseases and infections can be transmitted from one person to another.

Using a syringe is not recommended for withdrawing insulin from the pen.

Combining Humulin R U-100 with a healthy diet and exercise can improve blood sugar control in individuals who have diabetes mellitus.

How Does Humulin N work?

Unlike regular human insulin, Humulin N takes longer to act and lasts longer. In addition to the prefilled KwikPen, Humulin N is also available as a U-100 vial.

Injecting Humulin N under the skin is a simple process. Avoid injecting it into muscles or veins. Units of insulin are measured in milligrams. Humulin N contains 100 units/mL, as do other U-100 insulins. Use a syringe marked for preparations of U-100 insulin when using the Humulin N U-100 vial.

Humulin N should not be used:

– Following mixing, the insulin substance (the white material) stays at the bottom of the bottle, or

– the insulin is clumped together after mixing

Speak with your physician if your insulin requirements appear to be changing.

Needles and pens should only be used by one patient and should not be shared, even by healthcare facilities, as infection or disease can spread from one to another.

Do not use a syringe to extract insulin from the pen.

How Does Humulin 70/30 Work?

The Humulin 70/30 KwikPen and the Humulin 70/30 U-100 vial combine Humulin N’s short and intermediate-acting characteristics and regular human insulin (Humulin R U-100).

Subcutaneous injections of Humulin 70/30 are performed. Veins and muscles should not be injected with the product. Units determine the dose of insulin. Humulin 70/30 contains 100 units/mL, and other U-100 insulins do. A syringe marked for U-100 insulin should be used with the Humulin 70/30 vial.

Humulin 70/30 should not be used for the following reasons:

– If the white material (insulin substance) remains at the bottom of the bottle after mixing

– If solid particles are noticeable within the vial/pen. 

Your insulin requirements may change if solid particles are visible.

As infection or disease can be transmitted from one person to another when using pens and needles, they should not be shared, even in healthcare facilities.

Syringes should not be used to withdraw insulin from the pen.

Important Considerations

Insulin, including Lilly Humulin insulins, can lower blood sugar levels (hypoglycemia). The following symptoms can be associated with severe hypoglycemia: disorientation, unconsciousness, seizures, or death.

Neither the needle nor the Humulin KwikPen should ever be shared. Needles or syringes cannot be transferred if using Humulin vials. It is possible to infect someone or catch a severe infection from someone else by sharing.

Any change in insulin dosage must be done under the supervision of a physician.

Strength changes, changes in manufacturer, changes in type (e.g., regular, NPH, analog), species changes, or differences in the manufacturing method may require a dosage adjustment.

A change in dosage may be required by some patients who take Humulin. During the first several weeks or months, an adjustment may be necessary.

High blood sugar (hyperglycemia) may develop when the body does not create enough natural insulin, high blood sugar (hyperglycemia) may produce. Long-term hyperglycemia can cause diabetic ketoacidosis (DKA) in people with type 1 or insulin-dependent diabetes. The condition may be fatal.

Ensure that the insulin you receive from the pharmacy has the correct name and letter designation by checking the carton and bottle labels.

When Humulin has expired or frozen, it should not be used.

Needles and syringes should not be shared, as you might contract an infection.

If you are bearing a child (or plan on becoming pregnant) and you are taking any medications, including prescription drugs and non-prescription medicines, natural vitamins, and herbal supplements, inform your healthcare providers before you use Lilly Humulin insulin.

When taken with Lilly Humulin insulin, certain pills called thiazolidinediones or “TZDs” can cause serious side effects, like heart failure. Tell your healthcare provider or doctor right away if you have a new or worsening heart failure symptom, such as shortness of breath, swelling of your ankles or feet, or weight gain.

Symptoms of Humulin

Common side effects include:

Hypoglycemia (low blood sugar). Find out what your doctor recommends for treating low blood sugar. Each person may experience different symptoms.

Symptoms of allergies include swelling and redness at the injection site (lipodystrophy). Thickened or pitted skin at the injection site and rashes and itching.

Hypoglycemia: what is it? 

If you take too much Humulin, you may develop hypoglycemia. You should understand hypoglycemia, what it looks like, and how to manage it if it happens to you. Hypoglycemia can have life-threatening consequences iThe term hypoglycemia refers to low blood glucose levels (below 4mmol/l) that are not enough to support normal body functions (below 4mmol/l). Usually, there are warning signs before ‘hypos’ begin.

People may experience a different array of symptoms, including: 

– Shakiness and trembling
– Perspiration
– Anxiety or irritability
– Skin becomes pale
– Increased pace in a heartbeat
– Tingling in the lips
– Blurred sight
– Hunger
– Sadness
– Fatigue
– Headaches
– Difficulty concentrating

Before You Use Humulin

Please inform your doctor if you expect a child or plan to conceive. Be sure to mention the following:

– Allergic reactions. If you are concerned that the medicine may cause an allergic reaction, ask about your health conditions, including liver, kidney, and heart problems. 

– You should consider all the drugs you take, especially a class of medications called thiazolidinediones. Don’t forget to add over-the-counter medicines, vitamins, and herbal supplements.

Humulin Questions & Answers

I missed my dose. What should I do?

It is rarely an emergency to forget your Humulin. It is possible that your blood glucose levels are high, that you feel tired or thirsty, or that you pass more urine than usual. It is best to seek medical attention. You will receive different advice depending on when you realize that you forgot to take your Humulin.

How often should I check my blood glucose level?

You may need to measure your fasting blood glucose before eating breakfast first thing in the morning. Discuss your testing schedule with your healthcare professional. Keep a blood glucose diary for your healthcare professional.

In the event of illness, what should I do?

Your blood glucose may rise as a result of several common illnesses. As you feel ill, you may not feel like eating or taking your insulin treatment as expected, but do not forget to follow these basic guidelines in case of sickness: Stay on top of your insulin. Please note that your insulin requirements may increase when you are feeling ill. If you are sick, talk to your healthcare provider about the steps you should take. It would be best to monitor your blood sugar level and check your ketones. Testing your blood sugar 2–4 hours a day will indicate whether you need to take more insulin. Ketones should be contained in your urine or blood regularly. High blood sugar levels and moderate or high ketones can indicate that you need more insulin; you should talk to your doctor, pharmacist, or healthcare professional about this.

Are there any considerations when driving?

It is generally not a problem if you take insulin while driving. Nevertheless, there are special rules. Are there any risks? If you take insulin while going, you are at risk of developing hypoglycemia. Do not drive until you and your Healthcare Professional have taken steps to control your blood glucose levels. If you experience frequent ‘hypos’ or find it challenging to recognize when you are going into a state of ‘hypo,’ you will have to stop driving.