Trulicity

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Trulicity: What is it?

The diabetes medicine Trulicity (dulaglutide) controls glucose levels in the blood.

Adults with diabetes mellitus type 2 can control their blood sugar with Trulicity plus diet and exercise.

Trulicity reduces the risk of heart attacks and strokes in patients with cardiovascular disease and type 2 diabetes.

Type 1 diabetes cannot be treated with Trulicity.

Before Taking Trulicity

Taking Trulicity may not be safe for patients with any of the following conditions:

– MEN-2 (tumors in your glands);

– an individual with a familial or personal history of medullary thyroid carcinoma;

– diabetes (talk to your doctor for treatment).

Be sure to tell your doctor, healthcare provider, or nurse if you experience any of the following:

– A pancreatic disorder;

– an intestinal or stomach disorder;

– A condition characterized by gastroesophageal reflux disease (GERD) or sluggish digestion;

– diabetes-related eye problems (retinopathy);

– chronic liver disease, and renal failure.

Animal studies have shown that Trulicity causes thyroid cancer or thyroid tumors. Regular users of the drug are not known to experience these side effects. Check with your doctor if you’re concerned.

There is no known risk to unborn babies from dulaglutide. Please inform your physician if you plan on becoming pregnant.

Using this medicine while breastfeeding may not be safe. Consult with your doctor for more information.

Trulicity Warnings 

The use of Trulicity is not recommended if you have Multiple Endocrine Neoplasia type 2 (MEN 2), medullary thyroid carcinoma (a type of thyroid cancer), or a personal or family history of thyroid cancer. This medicine should not be used if you are in a state of diabetic ketoacidosis (consult your doctor).

Animal studies have shown that Trulicity causes thyroid cancer or thyroid tumors. Regular users of the drug are not known to experience these side effects. Be sure to consult your doctor.

Your thyroid may be affected if you have symptoms such as swelling in your neck, difficulty swallowing, hoarseness, or shortness of breath.

Trulicity Usage

Follow your doctor’s instructions when using Trulicity. Please follow instructions on all prescription labels and read all medication guides and instructions. Occasionally, your doctor may need to adjust the dose.

You will be administered Trulicity once a week. Every week, take this medication simultaneously on the same day. If your dosing day is changed, it is recommended that you wait at least three days between doses.

Food or no food may be consumed with this medication.

Follow all instructions on your prescription label. If you don’t understand these instructions, consult your physician or pharmacist.

Trulicity will be injected into the right parts of your body. A different injection site will be used for each injection. It is not recommended to administer the injection twice.

Low blood sugar (hypoglycemia) can lead to weakness, hunger, dizziness, confusion, anxiety, and shaking. If you are suffering from hypoglycemia, take something that raises blood sugar rapidly, such as fruit juice, hard candy, crackers, raisins, or soda that is not on a diet.

When you suffer from severe hypoglycemia, your doctor may prescribe a glucagon injection kit. You should ensure that close family members or friends are aware of administering this injection in case of an emergency.

Keeping an eye out for hyperglycemia signs (increased thirst or urination) will also help.

Exercise, alcohol consumption, and skipping meals can affect blood sugar levels. Stress, illness, and surgery can affect blood sugar levels as well. It is essential to discuss any changes with your doctor or healthcare provider before making adjustments.

A pre-filled syringe or injection pen can be used one time only. Even if the medicine is still inside, throw it away after one use. Keep sharps containers in puncture-proof containers. Dispose of these containers following your state or local laws. It is essential to keep this away from children and pets. 

Protect Trulicity Pens from light by storing them in the refrigerator. Make sure you do not use them after their expiration date. This medicine should not be frozen, and if it has frozen, you should throw it away.

Symptoms of Trulicity

Whenever you experience any of the following reactions to Trulicity, stop using it immediately and find emergency medical help. This includes hives, difficulty breathing, lightheadedness, swelling of the face, lips, tongue, or throat.

If you experience any of the side effects below, call your doctor immediately.

– There may be nausea, vomiting, and severe pain in your upper stomach when you have pancreatitis;

– An impending thyroid tumor can be detected by swelling in the neck, difficulty swallowing, a lowered voice, or a feeling of shortness of breath;

– If you have low blood sugar symptoms, you may feel fatigued, hungry, sweaty, confused, irritable, dizzy, or feel jittery.

– The following symptoms can occur if you have kidney problems: decreased or no urination, swelling of your ankles or feet, fatigue, or shortness of breath.

If you experience vomiting or diarrhea or sweat more than usual, speak to your doctor. While using this medicine, it is easy to become dehydrated, leading to kidney failure.

Other side effects are possible as well. Call your doctor or healthcare provider for medical advice about symptoms and side effects. Please contact FDA at 1-800-FDA-1088 with any side effect concerns.

How will Trulicity be affected by other drugs?

Its effectiveness, duration of action, side effects, or decrease in effectiveness can be affected by interactions with Trulicity. It is not always necessary to stop one medication due to drug interaction, but it occasionally happens. If you are concerned about a medical interaction, speak with your doctor or healthcare provider. 

Trulicity may interact with medicines such as:

– acetazolamide

– anticonvulsants such as phenytoin

– Tricyclic antidepressants (such as amitriptyline, nortriptyline) and monoamine oxidase inhibitors (MAOIs) (such as selegiline, isocarboxazid, and phenelzine) are all effective antidepressants.

– antipsychotics, such as aripiprazole

– Metoprolol, labetalol, and atenolol may enhance hypoglycemic effects associated with beta-blockers

– bexarotene

– Medications such as prednisone and cortisone are corticosteroids

– ciprofloxacin

– Medications such as bumetanide and HCTZ, as well as bendroflumethiazide, are diuretics

– A combination of the HIV medications amprenavir, atazanavir, and fosamprenavir

– Estradiol and progesterone, for example, are hormones

– insulin (may increase risk of hypoglycemia)

– isoniazid

– Glimepiride and metformin are other medications used to control blood sugar levels or treat diabetes.

Questions and Answers About Trulicity 

Is Trulicity associated with weight loss?

Weight loss is not associated with Trulicity. However, some people may lose weight. When taking Trulicity, people typically lose between two and six pounds. Up to 30% of people gain weight while taking the drug. After a meal, Trulicity helps you feel satisfied because it allows you to feel complete. If you are overweight or have gastrointestinal side effects, you are more likely to lose weight if you start at a higher weight.

The toxin affects of alcohol may also be enhanced by Trulicity, resulting in flushing.

Any medication taken orally may be affected by Trulicity because it causes a delay in gastric emptying. However, the effects of other medicines did not seem to be involved in clinical trials.

Trulicity may interact with the following medications, which is not an exhaustive list. To find out about Trulicity’s possible interactions, consult the drug’s prescribing information.

Is Trulicity required to be refrigerated?

When not in use, keep Trulicity at a temperature of 36°F to 46°F (2°C to 8°C). Leaving Trulicity out of the refrigerator for up to 14 days without any adverse effects is possible at a temperature of no more than 86°F (30°C). After 14 days without being kept in a refrigerator, Trulicity should be disposed of in a sharps container. When Trulicity is frozen, it should not be used; it should not be used if it is frozen.

Is Trulicity compatible with insulin?

Trulicity is compatible with insulin. This may mean a reduction in insulin dosage. Combining Trulicity and insulin increases the chance of hypoglycemia (low blood sugar). Trulicity is suitable only for people with type 2 diabetes whose pancreas still produces insulin. Once a week, Trulicity is injected subcutaneously. Insulin and Trulicity are injected at different sites.

Can Trulicity be injected cold?

The Trulicity will sting more if you give it cold. Trulicity can be given cold, but an injection will be much more pleasant if you warm it up before giving it. As long as the pen is kept no warmer than 86°F (30°C) and not exposed to light or heat, a Trulicity pen may be left unrefrigerated for a maximum of 14 days.

If you take an injectable right from the refrigerator without letting it warm up first, it will sting when being injected.

Warming them up on a bench is the best way. The medicine should never be heated in a microwave, boiled, or cooked on a stove since this may destroy it.

If you wish to speed up the warming process, you can put the injection between your hands; however, be careful not to drop or damage the pen in any way.

How does Trulicity get injected?

It is easy to self-inject the Trulicity Pen, but it is best to get a demonstration from your physician or nurse before you try. Hold the pen directly in front of your skin and push the green injection button after removing the cap. Upon completion of the injection, you will hear a click followed by a second click ten to fifteen seconds later. Subcutaneous (under the skin) injections of Trulicity are given once a week into the upper arm, stomach area, or thigh.

Is Trulicity a type of insulin?

Trulicity (dulaglutide) is not an insulin. This type of treatment relies on beta cells, which are cells found in the pancreas responsible for secreting, storing, and releasing insulin.

GLP-1 receptor agonists such as Trulicity belong to a class of medicines known as GLP-1 receptor agonists. Incretin mimics are also known as GLP-1 receptor agonists.

During pregnancy, can I take Trulicity?

Based on animal reproductive studies, the fetus may have risks associated with a drug. There are insufficient human data to assess a drug’s association with significant congenital disabilities.

Risks to the fetus may outweigh potential benefits; use only if benefits outweigh risks.