Farxiga (Dapagliflozin Propanediol Monohydrate)

Purchase genuine, Health Canada-approved Farxiga from licensed Canadian pharmacies through Insulin Outlet. We guarantee adherence to all federal safety standards and provide secure, direct shipping of your discounted medication. Identical to the US product (with Canadian labeling), our Farxiga is never counterfeit or unauthorized. Order online above or call 1-888-238-0872 for convenient access.

Farxiga is a prescription medication containing the active pharmaceutical ingredient dapagliflozin. Dapagliflozin belongs to a class of drugs known as sodium-glucose co-transporter 2 (SGLT2) inhibitors.

Insulin Outlet provides a safe and reliable platform for individuals to purchase Farxiga. We are committed to ensuring the authenticity and quality of all medications we offer, so you can be sure to receive premium healthcare for a fraction of the price it costs in the US.

Farxiga is indicated for several important therapeutic uses in adults:

• Management of Type 2 Diabetes Mellitus: It helps to lower blood sugar levels in adults with type 2 diabetes.
• Reduction of Cardiovascular Risk in Heart Failure: It is used to reduce the risk of cardiovascular death and hospitalization for heart failure in adults.
• Reduction of Kidney Disease Progression: It is also used to reduce the risk of sustained estimated glomerular filtration rate (eGFR) decline, end-stage kidney disease, cardiovascular death, and hospitalization for heart failure in adults with chronic kidney disease who are at risk of progression.

Farxiga exerts its therapeutic effects by targeting the sodium-glucose co-transporter 2 (SGLT2) protein located in the proximal renal tubules of the kidneys.

Here’s a breakdown of the mechanism:

1. Inhibition of SGLT2: Dapagliflozin, the active ingredient in Farxiga, acts as an inhibitor of SGLT2. This protein is primarily responsible for reabsorbing glucose from the filtered blood back into the bloodstream.
2. Reduced Glucose Reabsorption: By inhibiting SGLT2, Farxiga reduces the amount of glucose that is reabsorbed by the kidneys.
3. Increased Urinary Glucose Excretion: Consequently, more glucose remains in the renal tubules and is excreted in the urine. This process of increasing glucose excretion through urine is called glucosuria.
4. Lowering Blood Glucose Levels: The net effect of reduced glucose reabsorption and increased urinary excretion is a decrease in overall blood glucose levels.

The easiest approach is to follow the instructions provided by your healthcare professional and the information included in the official patient leaflet that comes with your medication.

Here we present general guidance on how prescription medications like Farxiga are typically used:

1. Read the Medication Guide/Patient Information Leaflet: Before you start taking Farxiga, carefully read the patient information leaflet that comes with your medication. This leaflet contains important information about how to take Farxiga, potential side effects, and other warnings.
2. Take Exactly as Prescribed: Your doctor will prescribe the appropriate dose and frequency of Farxiga for your specific condition. Do not change your dose or stop taking Farxiga without talking to your doctor.
3. Timing of Dosage: Farxiga is typically taken once daily, by mouth. Your doctor may specify whether to take it at a particular time of day. You can usually take Farxiga with or without food.
4. Swallowing the Tablet: Take the Farxiga tablet orally with a full glass of water. Ensure you swallow it whole; avoid crushing, chewing, or breaking it unless your healthcare provider has given you specific directions to do so.
5. If You Miss a Dose: If you realize you’ve missed a dose, take it immediately. However, if your next scheduled dose is approaching soon, skip the missed one and continue with your regular dosing schedule. Never take two doses at once to compensate for a missed dose.
6. Storage: Store Farxiga according to the instructions on the packaging. Typically, this involves keeping it at room temperature, away from moisture and heat, and out of reach of children.

Available Dosages:

Farxiga tablets are available in two strengths:

• 5 mg
• 10 mg

Recommended Dosing Schedule:

The recommended dosage of Farxiga varies depending on the condition being treated and the patient’s individual needs. It is crucial to follow your doctor’s specific instructions. The following are general guidelines:

For Glycemic Control in Adults and Pediatric Patients (10 years and older) with Type 2 Diabetes Mellitus:

• The recommended starting dose is 5 mg orally once daily, taken in the morning, with or without food.
• For additional glycemic control in patients tolerating the 5 mg dose, the dose can be increased to 10 mg orally once daily.
• The maximum recommended dose for type 2 diabetes is 10 mg once daily.
• In patients with type 2 diabetes and an estimated glomerular filtration rate (eGFR) greater than or equal to 45 mL/min/1.73 m², the dosage recommendations are the same as in patients with normal renal function.
• Farxiga is generally not recommended for glycemic control in patients with type 2 diabetes mellitus with an eGFR less than 45 mL/min/1.73 m² as it is likely to be ineffective in this setting due to its mechanism of action.¹

It is vital to discuss your complete medical history with your healthcare provider before taking Farxiga. Certain conditions may increase your risk of side effects or affect whether Farxiga is the right medication for you.

Contraindications:

• History of Serious Hypersensitivity Reaction: Do not use Farxiga if you have had a serious allergic reaction to dapagliflozin or any of the inactive ingredients in the medication.
• Severe Renal Impairment, End-Stage Renal Disease, or Dialysis: Farxiga is contraindicated in patients with severely impaired kidney function (eGFR < 30 mL/min/1.73 m²) or those requiring dialysis. It is unlikely to be effective in these populations and may increase the risk of adverse effects.

Precautions:

• Diabetic Ketoacidosis (DKA): Farxiga significantly increases the risk of DKA, a serious condition requiring hospitalization and potentially leading to death.
• Volume Depletion (Dehydration): Farxiga can cause intravascular volume depletion, leading to dizziness, lightheadedness, fainting, or low blood pressure, especially upon standing (orthostatic hypotension).
• Urosepsis and Pyelonephritis (Serious Urinary Tract Infections – UTIs): An increased risk of serious UTIs, including kidney infections and urosepsis (a life-threatening response to infection), has been reported with SGLT2 inhibitors like Farxiga.
• Hypoglycemia (Low Blood Sugar): The risk of hypoglycemia is increased when Farxiga is used in combination with insulin or insulin secretagogues (e.g., sulfonylureas).
• Genital Mycotic Infections (Yeast Infections): Farxiga increases the risk of genital yeast infections in both women and men.
• Necrotizing Fasciitis of the Perineum (Fournier’s Gangrene): This rare but serious and potentially life-threatening bacterial infection of the tissue under the skin in the genital and perineal area has been reported with SGLT2 inhibitors.2

Like all medications, Farxiga can cause side effects. It’s important to be aware of both common and serious side effects and to discuss any concerns with your healthcare provider.

Common Side Effects:

• Female and Male Genital Mycotic Infections
• Urinary Tract Infections (UTIs)
• Increased Urination
• Nasopharyngitis (Common Cold)
• Nausea
• Increased Thirst:
• Constipation

Serious Side Effects:

These side effects are less common but can be serious and require prompt medical care.

• Diabetic Ketoacidosis (DKA):
  • Nausea
  • Vomiting
  • Abdominal pain
  • Tiredness
  • Trouble breathing
  • Fruity odor to the breath
  • High levels of ketones in your urine or blood
• Serious Urinary Tract Infections (UTIs) including Pyelonephritis and Urosepsis:
  • Fever
  • Chills
  • Pain in your back or side
  • Severe pain when urinating
  • Cloudy or bloody urine
• Volume Depletion (Dehydration):
  • Dizziness
  • Lightheadedness
  • Fainting
  • Orthostatic hypotension (a drop in blood pressure when standing up)
• Hypoglycemia (Low Blood Sugar):
  • Shaking
  • Sweating
  • Dizziness
  • Confusion
  • Hunger
  • Rapid heartbeat
• Serious Allergic Reactions:
  • Rash
  • Hives
  • Swelling of the face, lips, tongue, or throat
  • Trouble breathing or swallowing
• Necrotizing Fasciitis of the Perineum (Fournier’s Gangrene):
  • Pain, tenderness, redness, or swelling in the genital or perineal area
  • Fever
  • Feeling unwell
• Kidney Problems

To ensure your safety and the effectiveness of Farxiga, it’s crucial to inform your doctor about every medication you’re using. This includes prescription and non-prescription drugs, as well as vitamins and herbal supplements.

This medication can interact with:

• Diuretics: Taking Farxiga with diuretics like furosemide or hydrochlorothiazide can increase the risk of dehydration.
• Insulin or Insulin Secretagogues (e.g., Sulfonylureas): When Farxiga is used in combination with insulin (e.g., insulin lispro, insulin glargine) or insulin secretagogues (e.g., glipizide, glimepiride), there is an increased risk of hypoglycemia (low blood sugar).
• Lithium: Co-administration of Farxiga with lithium may decrease serum lithium concentrations. This could potentially reduce the therapeutic effect of lithium.