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Onexton (Clindamycin Phosphate, Benzoyl Peroxide)



SKU: DP-210 Category:


Onexton is a dermatologist-prescribed topical gel that combines two powerful active ingredients – Clindamycin and Benzoyl Peroxide. This combination creates a potent formula designed to target and treat acne-related issues. Clindamycin is an antibiotic that helps to fight acne-causing bacteria, while Benzoyl Peroxide works by reducing inflammation and unclogging pores. By combining these two elements, Onexton offers a comprehensive solution for individuals struggling with various forms of acne.

Onexton is primarily used to treat acne vulgaris, a common skin condition characterized by the presence of pimples, blackheads, whiteheads, and inflamed skin. Acne can have a significant impact on one’s self-esteem and overall well-being. Onexton’s dual-action approach makes it effective against mild to moderate cases of acne, addressing both the bacterial aspect and the inflammation, thus promoting clearer skin.

Dermatologists often prescribe Onexton to individuals dealing with acne issues that haven’t responded well to over-the-counter treatments. It’s important to note that Onexton is a prescription-only medication, meaning it can only be obtained through a healthcare professional. Before prescribing Onexton, dermatologists assess the severity of the acne and the patient’s skin type to ensure the best possible results.

Warnings and Precautions

Navigating any medical treatment requires informed decision-making. Before incorporating Onexton into your skincare routine, it’s vital to understand the potential risks and precautions associated with its use. Here, we delve into the specifics to help you make an educated choice:

Allergic Reactions: A Note of Caution

Onexton contains active ingredients that might trigger allergic reactions in some individuals. If you’ve experienced allergic responses to any components of Onexton, it’s crucial to avoid its usage. Common symptoms of allergic reactions include itching, swelling, rash, or difficulty breathing. If any of these symptoms occur, discontinue use immediately and seek medical attention.

Skin Sensitivity and Irritation

While Onexton can effectively combat acne, it may also lead to skin sensitivity and irritation, especially during the initial phases of usage. This is a common occurrence and usually subsides as your skin adjusts to the treatment. To minimize irritation, start with a lower frequency of application, and gradually increase as your skin becomes accustomed to the medication.

Sun Sensitivity and Protection

Onexton can increase your skin’s sensitivity to sunlight. This means you’re more susceptible to sunburn and other sun-related skin damage. To protect your skin, apply a broad-spectrum sunscreen with a high SPF before stepping out. Wearing protective clothing and avoiding sun exposure during peak hours can further shield your skin.

Interaction with Other Products

To ensure the efficacy of Onexton, it’s advisable to avoid using other acne treatments or harsh skincare products simultaneously. Combining such products can lead to excessive dryness, irritation, and may even reduce the effectiveness of both treatments. Consult your dermatologist to create a tailored skincare routine that complements your Onexton usage.

Pregnancy and Nursing

If you’re pregnant or nursing, it’s crucial to consult your healthcare provider before using Onexton. The safety of this medication during pregnancy and lactation has not been firmly established, and your doctor can guide you in making the best decision for your unique situation.

Avoiding Contact with Eyes and Mouth

Onexton is designed for external use only. Avoid applying the medication near your eyes, mouth, or any other sensitive areas. In case of accidental contact, rinse thoroughly with water. If irritation persists, seek medical attention.

Side Effects

Side effects of Onexton can vary from person to person, and while some may experience none, others may encounter a range of effects. It’s important to remember that not everyone will experience these side effects, and they may also depend on factors such as skin type, sensitivity, and individual response to the medication.

Common Skin Irritations

One of the side effects of Onexton is skin irritation, including redness, itching, and burning. These symptoms are usually mild and temporary, as your skin adjusts to the medication. It’s recommended to start with a small amount and gradually increase to minimize discomfort.

Dryness and Peeling

Many users report dryness and peeling of the skin, particularly during the initial weeks of using Onexton. This is a result of the medication’s exfoliating properties, which help shed dead skin cells. Using a gentle moisturizer can alleviate these symptoms and maintain skin hydration.

Sensitivity to Sunlight

Onexton can increase your skin’s sensitivity to sunlight. It’s crucial to apply a broad-spectrum sunscreen with an SPF of 30 or higher daily, even on cloudy days. Wearing protective clothing and avoiding prolonged sun exposure can further reduce the risk of sunburn.

Discoloration and Staining

Some users may notice temporary skin discoloration or staining, especially if the medication comes into contact with clothing or other fabrics. Being cautious with application and allowing the medication to fully absorb before getting dressed can minimize this issue.

Avoiding Harsh Products

To prevent exacerbating side effects, it’s advisable to avoid using harsh or abrasive skincare products while using Onexton. This includes products containing alcohol, retinoids, or alpha hydroxy acids, as they can intensify skin irritation.


When discussing drug interactions with Onexton, it’s vital to consider how different medications can impact its efficacy and potential side effects. Here’s a comprehensive look at some key factors to keep in mind:

Antibiotics and Onexton

When using other antibiotics alongside Onexton, there’s a potential risk of overloading the body with antibacterial agents. This can lead to skin sensitivity, redness, and dryness. To avoid these effects, consult your healthcare provider to determine the best course of action.

Retinoids and Onexton

Combining Onexton with retinoid-based medications can enhance the risk of skin irritation and peeling. It’s recommended to use these medications at different times of the day to minimize adverse effects.

Oral Corticosteroids and Onexton

Using oral corticosteroids with Onexton might increase the risk of skin thinning and delayed wound healing. Your healthcare provider will guide you on managing this combination safely.

Astringents and Onexton

Astringent skincare products can intensify skin dryness and irritation when used with Onexton. Opt for gentle, non-comedogenic moisturizers to counterbalance these effects.

Anticoagulants and Onexton

While topical medications like Onexton are less likely to interact with anticoagulants, it’s still essential to inform your healthcare provider about all medications you’re using, including over-the-counter ones.

Herbal Supplements and Onexton

Certain herbal supplements, such as St. John’s wort, can affect the efficacy of Onexton. Always inform your healthcare provider about any supplements you’re taking.

Sulfur-Based Products and Onexton

Combining sulfur-based products with Onexton might lead to excessive skin dryness and peeling. Your dermatologist can help you create a skincare routine that minimizes these effects.

Prescription Medications and Onexton

Before starting any new prescription medication while using Onexton, consult your doctor to ensure compatibility and avoid potential interactions.

Sunscreen and Onexton

Onexton can make your skin more sensitive to the sun. Ensure you use a broad-spectrum sunscreen with a high SPF to protect your skin while using this medication.

Alcohol and Onexton

While Onexton itself doesn’t interact negatively with alcohol, excessive alcohol consumption can worsen skin conditions, counteracting the benefits of the medication.

How to Apply

  1. Cleanse Your Face Thoroughly: Before applying Onexton, start with a clean slate. Gently wash your face with a mild cleanser and lukewarm water to remove dirt, oil, and makeup. Pat your face dry with a clean towel.
  2. Apply a Pea-Sized Amount: Squeeze a small amount of Onexton, about the size of a pea, onto your fingertip. This should be enough to cover the entire affected area.
  3. Dot the Medication: Using your fingertip, dot the Onexton evenly across the areas with acne or as directed by your dermatologist. Avoid applying the medication to unaffected areas.
  4. Gently Massage: Using your clean fingertips, gently massage the Onexton into your skin in a circular motion. Be cautious not to rub vigorously, as acne-prone skin can be sensitive.
  5. Let It Absorb: Allow the medication to absorb into your skin before applying any additional skincare products. This usually takes a few minutes.


Store at Room Temperature

Onexton should be stored at room temperature, typically between 68°F and 77°F (20°C and 25°C). Avoid exposing it to extreme heat or cold, as temperature fluctuations can affect its chemical composition.

Keep Away from Moisture

Moisture can degrade the potency of Onexton, so store it in a dry place. The bathroom might not be the best choice due to its humidity. Instead, opt for a cool and dry area, like a medicine cabinet or a shelf in your bedroom.

Original Packaging

Keep Onexton in its original packaging to protect it from light and air. The packaging is designed to preserve the stability of the medication. If the packaging becomes damaged, consider transferring the gel to an airtight container.

Avoid Direct Sunlight

Direct sunlight can cause the active ingredients in Onexton to break down. Store the medication in a place where it won’t be exposed to direct sunlight. A drawer or cabinet works well to shield it from UV rays.

Away from Children and Pets

Store Onexton out of reach of children and pets. The gel is meant for topical use and should not be ingested. Placing it in a high cabinet or a locked drawer can prevent accidental exposure.

Do Not Freeze

Freezing temperatures can alter the consistency and efficacy of Onexton. Keep it at room temperature and avoid storing it in the refrigerator.

Keep Lid Secure

Make sure the lid of the Onexton container is tightly closed when not in use. This prevents air and moisture from entering the container, maintaining the gel’s quality.

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