- Warnings and Precautions
- Before Using Humalog
- Side Effects
- Drug Interactions
Humalog vials contain 100 units (10 milliliters). Humalog (insulin lispro) is fast-acting insulin used to treat type 1 and type 2 diabetes patients manage their blood sugar levels.
Insulin lispro is closely related to human insulin, which is the natural hormone produced by the pancreas. Humalog also has their products available in KwikPens: 100 units (with available cartridges), 200 units, Mix 25 (with available cartridges) and Mix 50.
This manufactured insulin is safe and effective in treating both adults and children over the age of 3, whether Humalog is safe and effective for type 1 diabetes under three or children with type 2 diabetes.
Humalog is a substitute for human insulin and is used to control glucose levels. Since the molecules in this insulin have been modified, it works faster than regular human insulin.
It increases the rate at which the body converts glucose to glycogen stored in the muscle to be later used as energy.
The other ingredients in Humalog vials are glycerol, m-cresol, zinc oxide, dibasic sodium phosphate 7 H2O, and water for injection. Hydrochloric acid or sodium hydroxide may have been used to adjust the acidity.
Warnings and Precautions
Using Humalog vials may cause a drop in blood sugar levels (hypoglycemia).
Always check your insulin labels when receiving them from your pharmacy or before use, so it is not potentially confused for other medications you are taking.
Some patients had reported experiencing hypoglycemia when they switched to human insulin from animal insulin.
Your insulin dosage may need to change if you take any of the following medications: contraceptive pills, oral hypoglycemics, steroids, thyroid medication, sulpha antibiotics, acetylsalicylic acid, antidepressants, beta-blockers. See the drug interactions tab for more information.
Speak with your doctor if you are taking any medications or supplements not listed above.
Your ability to concentrate may be affected due to hypoglycemia. For this reason, you should not drive or operate machinery while using this insulin. Symptoms may differ for each patient.
Some may experience heart failure, shortness of breath, increased weight gain, and localized swelling (edema).
Rotate injection sites to avoid causing skin damage such as lumps. Humalog will not work well if injected into a lumpy area.
Your doctor may recommend closely monitoring your blood sugar levels and adjusting your insulin dosage and other antidiabetic medications.
Carry glucose tablets, candy, or sugary drinks if you experience low blood sugar (mild hypoglycemia).
Do not use Humalog if you are experiencing hypoglycemia (low blood sugar) or have an allergy to insulin lispro or other ingredients in this medication.
Before Using Humalog
It would be best if you told your doctor:
• if you have had an allergic reaction to any medicine you have used previously to treat your current condition.
• if you have or have had any medical conditions, especially kidney, liver, or heart disease.
• if you experience fluid retention, especially in the hands, ankles, or feet.
• if you often have hypoglycemia (low blood sugar) or if you have trouble recognizing the symptoms of hypoglycemia. Under certain conditions, the early warning signs of hypoglycemia can be different or less pronounced.
• if you drink alcohol.
• if you are ill. Illness, especially with nausea and vomiting, may cause your insulin needs to change. Even if you are not eating, you still require insulin. You and your doctor should design an insulin plan for those times when you are sick.
• if you are exercising more than usual. Exercise may lower your need for insulin. Exercise may also speed up the effect of an insulin dose, especially if the training involves the injection site (e.g., the leg should not be used for injection just before running).
Humalog vials come already dissolved in water, so you don’t need to mix them; however, it should only be used if it appears clear, colorless with no particles, like water.
Humalog vials work very quickly and can last for shorter periods than soluble insulin. Typically this insulin is used 15 minutes before starting your meal.
Your doctor may recommend taking Humalog vials in combination with longer-lasting insulin (such as Lantus).
1. First, wash your hands
2. Clean the skin and rubber stopper on the Humalog vial as instructed before injection.
3. Use a clear, sterile syringe to pierce the rubber stopper to draw the recommended dosage amount.
4. Inject insulin under the skin within 1cm from the last injection.
5. After injection, leave the need in the skin for 5 seconds to ensure you have taken the whole dose
Rotate injection sites as instructed. Medication can be used in the thigh, upper arm, buttock, or abdomen.
Do not rub the area after injection.
Do not share insulin with other people as this can spread blood-borne pathogens.
Do not inject directly into a vein.
Do not mix Humalog vials with other insulin manufacturers or with animal insulin.
Do not administer Humalog insulin intravenously. A doctor should only do this.
Similar to any medication, Humalog insulin may cause side effects; however, not everyone experiences them. Humalog insulin side effects may include sweating, increased heartbeat, difficulty breathing/wheezing, drop in blood pressure, and rashes all over the body.
Some experienced localized allergies at the injection site, which may include swelling, itching, or redness. Typically it clears up within a few days to weeks. Notify your doctor if you experience allergic reactions.
Amyloid (lumps under the skin) may be caused at injection sites due to protein build-up. Repetitive injecting into a single site may also cause lipohypertrophy (skin thickening) or lipoatrophy (shrinking fatty tissue). To avoid these skin issues from happening, you should rotate injection sites.
Edema (fluid retention; swelling of ankles and arms) has been reported at the start of treatment or during changes in blood glucose control.
If you are feeling ill after taking Humalog insulin, you made need to adjust your dosage levels. Even if your eating habits have changed, you still require insulin. Test your blood & urine and consult a doctor.
Also, speak to your doctor or pharmacist if you experience any side effects, including those not listed above.
Hypoglycemia or low blood sugar means there is not a sufficient amount of sugar in the blood. This can be caused by numerous factors, including if you take too much insulin, you delay or miss meals or change your diet, you exercise too much before/after meals, you have an illness or infection, you have trouble with your heart, liver or kidneys and alcohol may affect blood sugar levels.
Symptoms of low blood sugar include tiredness, shakiness or nervousness, headaches, cold sweats, increased heartbeat, and feeling sick.
Hyperglycemia or too much sugar in the blood can lead to ketoacidosis. It happens when your body does not have enough insulin and can be brought about by not taking your prescription insulin-like Humalog, taking less insulin than advised, fever, emotional stress, or infection, eat more than your recommended diet allows.
Symptoms include flushed face, increased thirst, no appetite, feeling sick, fruit smell on the breath, rapid pulse, and heavy breathing.
If you are feeling any of these symptoms, you should contact your doctor.
Tell your doctor if you are taking any other medicines, including those you buy without a prescription from your pharmacy, supermarket, or health food shop.
Some medicines may affect the way Humalog works. These include:
• oral antidiabetic medicines
• medicines that affect your metabolism (corticosteroids such as prednisone, cortisone)
• medicines used for oral contraception
• medicines used in thyroid replacement therapy
• certain antibiotics used to treat tuberculosis, such as isoniazid
• medicines such as aspirin or other salicylates
• certain medicines used to treat depression
• certain medicines used to treat asthma, such as salbutamol or terbutaline
• medicines used to treat high blood pressure or other heart conditions
• certain medicines used to treat people with growth disorders and tumors, such as octreotide
• medicines used to treat hormone-related disorders, such as danazol
• thiazolidinediones (TZDs), also used to treat type 2 diabetes; when used with insulin, there may be an increased risk of fluid retention and heart disease.
Your doctor or pharmacist has more information on medicines to be careful with or avoid while using Humalog. Tell your doctor about these medicines before you use Humalog.
If you are pregnant or breastfeeding, then you may require adjusting your insulin dosages. Typically dosage amounts may drop during the first trimester of pregnancy and increase during the second and third. Consult your doctor about recommended dosage.
Before first use, Humalog insulin vials should be stored in a refrigerator with temperatures between 2°C – 8°C. You may keep it refrigerated (between 2°C – 8°C) or at room temperature when in use. Never store this medication in a freezer or near heat or sunlight.
Keep insulin out of reach from children.
Discard medication after 28 days.
Do not dispose of via wastewater or household water. Speak to your pharmacist about how to properly dispose of medication. Proper insulin disposal helps protect the environment (see the disposing tab for more information).
If your doctor tells you to stop using Humalog or find your vials have passed their expiry date, please return any leftover vials to your pharmacist.
Needles should be disposed of in a sharps container or similar puncture-proof container composed of hard plastic or glass. Ask your doctor, nurse, or pharmacist where you can dispose of the container once it is complete.