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Rybelsus (Semaglutide) Tablets

30 tabs for $299.79

Rybelsus - 3mg
Rybelsus - 7mg
Rybelsus - 14mg
SKU: GP-27 Category:


Rybelsus (semaglutide) is a brand-name prescription medication that’s FDA-approved to treat type 2 diabetes. The drug helps control blood sugar in adults when used with diet and exercise. Semaglutide is a diabetic medication that works differently from insulin. It can help diabetics better manage their blood glucose by increasing insulin release, slowing down digestion, reducing glucose production in the liver, and promoting a feeling of fullness. This type of medication is usually added to other diabetic treatments (such as insulin and the use of insulin plants).

Rybelsus should not be the first medication you try to manage type 2 diabetes if diet and exercise don’t work. Currently, Rybelsus isn’t approved for treating diabetes type 1 or diabetic ketoacidosis, a severe complication of diabetes that occurs when the body produces excessive amounts of blood acids called ketones due to a lack of insulin. This imbalance can be life-threatening if not promptly addressed.

study has shown that Rybelsus helps lower blood sugar more than a placebo (a treatment with no active drug). Researchers used blood tests to measure the level of hemoglobin A1c (HbA1c), a marker of blood sugar control, , which reflects an individual’s average blood sugar levels over the preceding two to three months. Target values of less than 7% are common for HbA1c, but this varies from person to person depending on age and pregnancy status. Talk with your doctor about the target goal for your treatment. Rybelsus works in the same way as Trulicity and has become more common for weight-loss enthusiasts.

When discussing medications with your doctor, be open about your current prescriptions. Semaglutide may not interact well with medications like Jardiance. Open communication ensures optimal treatment.

Rybelsus significantly reduced the HbA1c levels of adults with type 2 diabetes 1.2% to 1.4% during the 26-week study. In contrast, people taking a placebo experienced a decrease of only 0.3%. Around 69% to 77% of people taking Rybelsus had HbA1c levels less than 7%, compared with 31% of people taking a placebo.

Side Effects

Rybelsus can cause mild or severe side effects. Listed below are some of the main side effects of Rybelsus. We have not included all potential side effects.

Rybelsus may cause side effects, so speak with your doctor or pharmacist. Your physician can provide you with tips on how to manage any side effects that are bothersome.

The most common mild side effects of Rybelsus can include:

  • Nausea and vomiting
  • Belly pain
  • Diarrhea
  • Decreased appetite
  • Constipation
  • Weight loss

The majority of these side effects can subside within a few days or weeks. The nausea will usually subside if you continue taking semaglutide. If any of these effects persist or worsen, tell your doctor or pharmacist.

It is imperative to remember that your physician prescribed this medication because he or she believes the benefit to you outweighs the risk of side effects. There are typically no severe side effects associated with this medication.

  • Hypoglycemia (See Hyploglycemia and Rybelsus tab for more information)
  • Pancreatitis
  • Diabetic retinopathy
  • Kidney problems

If you experience any serious side effects, tell your doctor right away. These include: kidney problems (such as change in urine amount), vision changes (such as decreased/blurred vision).

A very serious (perhaps fatal) disease of the pancreas (pancreatitis) has rarely been caused by semaglutide. If you experience any of these symptoms of pancreatitis, you need medical attention.

For medical advice about side effects in the US, consult your doctor. FDA can be contacted at 1-800-FDA-1088 or at www.fda.gov/medwatch if you experience side effects.

Before Usage

Rybelsus should not be shared.

Learn how to manage diabetes with medication, diet, exercise, and regular medical examinations by attending a diabetes education program.

Understand the symptoms of high and low blood sugar and how to treat low blood sugar. Make sure that you regularly check your blood sugar.

While taking this medication, you may need to have lab and/or medical tests (such as kidney function, fasting blood glucose, hemoglobin A1c). You should keep all medical and lab appointments. You should discuss this with your doctor.

Semaglutide is a prescription medication. Before you start taking it and before you refill it, be sure to read the Medication Guide. Ask your doctor or pharmacist if you have any questions. You can also reach out to Insulin Outlet and ask for a pharmacy consultation. We will be happy to arrange an appointment for you.

You should not take semaglutide if you are allergic to it or if you have any other allergies. Inactive ingredients in this product may cause allergic reactions or other problems. Consult your pharmacist for more information.

Tell your doctor or pharmacist if you have a medical history of: diabetic retinopathy, pancreatitis, kidney problems, stomach/intestinal disorders (such as gastroparesis, digestion problems).

In addition, people who are allergic to semaglutide or any of the ingredients of Rybelsus should not take Rybelsus if they have thyroid cancer or Multiple Endocrine Neoplasia Syndrome (including family history).

Semaglutide may cause side effects in people with certain medical conditions. Make sure your doctor is aware of any of the following conditions. You may need to be monitored more closely. Tell your doctor if you have:

  • Diseases of the pancreas or kidneys
  • Trouble seeing
  • Hypoglycemia (low blood sugar levels) is frequent.
  • Taking insulin or diabetes medications (such as Adlyxin)
  • Plans on becoming pregnant, or are pregnant.


Rybelsus is FDA-approved for the treatment of type 2 diabetes in adults when used with diet and exercise.

If diet and exercise aren’t helping your type 2 diabetes, Rybelsus shouldn’t be the first medication that you try. The drug isn’t for people who have type 1 diabetes or a complication of diabetes called diabetic ketoacidosis. Also, Rybelsus hasn’t been studied in people who have had a pancreas problem known as pancreatitis.

Type 2 diabetes is a condition in which your blood sugar level becomes too high due to problems with insulin. Insulin is a hormone that your pancreas makes to help control blood sugar. With type 2 diabetes, either your body doesn’t respond well to insulin or doesn’t produce enough insulin.

Diabetes type 2 is the most common form of diabetes. Diabetes type 2 can cause health problems in several body parts if left untreated, such as the heart, eyes, and nerves. Complications include high blood pressure, diabetic retinopathy, and neuropathy (nerve damage).

This medication should be taken with plain water (no more than 4 ounces or 120 milliliters) once a day, unless otherwise directed by your doctor. Other beverages should not be consumed with this medication. It should be swallowed whole. Avoid splitting, chewing, or crushing the tablet. If you are taking any other medication by mouth, wait at least 30 minutes after taking semaglutide before eating, drinking, or taking anything else by mouth.

Ideally, you should eat between 30 and 60 minutes after taking semaglutide. This medication should be taken the same way every time.

According to your medical condition and your response to treatment, the dosage will be determined.

This medication may be started at a low dose and gradually increased by your doctor to reduce the risk of side effects. Make sure you follow your doctor’s instructions carefully.

Get the most benefit from this medication by taking it regularly. Make sure you take it at the same time each day to make it easier to remember.

Use this medication as prescribed and do not increase your dose. There will be no improvement in your condition, and your risk of side effects will go up.

You should tell your doctor if you don’t feel better or if you feel worse (high blood sugar or low blood sugar).


You should call 911 as soon as possible if someone is experiencing serious side effects from a Rybelsus overdose, such as passing out or trouble breathing. In any other case, call a poison control center right away. In the United States, dial 1-800-222-1222 to reach your local poison control center.

Hypoglycemia and Rybelsus

While semaglutide on its own usually does not cause low blood sugar (hypoglycemia), it may if this drug is combined with another diabetes medication. Your doctor, pharmacist, or dietitian can help you determine if any other diabetes medications should be lowered. A low blood sugar level may also be caused by excessive drinking, eating too little, or doing unusually heavy exercise. There may be sweating, shaking, fast heartbeats, hunger, blurred vision, dizziness, and tingling hands and feet. Keeping glucose tablets or gel on hand is a good habit when low blood sugar occurs. In the absence of these reliable sources of glucose, raise your blood sugar rapidly by eating table sugar, honey, candy, or drink fruit juice or non-diet soda. Consult your doctor or pharmacist if you miss a meal.

Hyperglycemia (high blood sugar) is characterized by increased thirst and urination. Contact your doctor right away if you experience these symptoms. The dose of your medication may need to be adjusted.

Drug Interactions

You may be more likely to have hypoglycemia (low blood sugar) if you take Rybelsus and medication in a drug class called sulfonylureas. (A drug class is a group of medications that work in a similar way.) Sulfonylurea drugs help treat type 2 diabetes.

You may be more likely to have hypoglycemia if you take Rybelsus and any type of insulin.

You should take Rybelsus at least 30 minutes before taking any other oral medications. (“Oral” refers to a drug that you swallow as a tablet, capsule, or liquid.) Otherwise, Rybelsus won’t work as well to treat your condition.

Rybelsus slows down how quickly your stomach empties, and this can change the way your body absorbs other medications. Because of this, your doctor may test you more often to make sure your medication is working well.

Before you start taking Rybelsus, tell your doctor about any medications you take. They can help advise you on when to take them and Rybelsus.

There may be an interaction between Rybelsus (semaglutide) and any of the following:

  • Acetylsalicylic acid (ASA)
  • Antipsychotics (e.g., olanzapine, quetiapine, risperidone)
  • Corticosteroids (e.g., beclomethasone, cortisone, dexamethasone, hydrocortisone, prednisone)
  • Diabetes medications (e.g., chlorpropamide, glyburide, insulin, linagliptin, metformin, rosiglitazone)
  • Disopyramide
  • Diuretics (e.g., hydrochlorothiazide, indapamide)
  • Epinephrine
  • Estrogens (e.g., estradiol, ethinyl estradiol, conjugated estrogen)
  • Glucagon
  • Goserelin
  • Hepatitis C antivirals (e.g., glecaprevir and pibrentasvir, ledipasvir, velpatasvir)
  • HIV protease inhibitors (e.g., lopinavir, ritonavir, saquinavir, tipranavir)
  • Hydroxychloroquine
  • Lanreotide
  • Levothyroxine
  • Mifepristone
  • Monoamine oxidase inhibitors (MAOIs; e.g., moclobemide, phenelzine, rasagiline, selegiline,
  • tranylcypromine)
  • Niacin
  • Nilotinib
  • Octreotide
  • Pasireotide
  • Progestins (e.g., cyproterone, levonorgestrel, medroxyprogesterone, norethindrone, progesterone)
  • Quinine
  • Quinolone antibiotics (e.g., ciprofloxacin, norfloxacin, ofloxacin)
  • Selective serotonin reuptake inhibitors (SSRIs; e.g., citalopram,  paroxetine, sertraline)
  • Sirolimus
  • Somatostatin
  • Sulfonamide antibiotics (“sulfas”; e.g., sulfisoxazole, sulfamethoxazole)
  • Sunitinib
  • Tacrolimus
  • Testosterone
  • Vorinostat

Ask your doctor or pharmacist about any of these medications that you are using. Your doctor may recommend that you:

  • discontinue taking one of the medications,
  • switch medications,
  • or alter the way you take one or both medications
  • leave everything as is.

It isn’t always necessary to stop using one medication because of an interaction between two others. Ask your doctor how any drug interactions are being managed or should be managed.

There could be interactions with other medications besides those listed above. Inform your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are using. You should also inform them if you take any supplements. If you use caffeine, alcohol, nicotine from cigarettes, or street drugs, tell your prescriber. All of these substances can affect the action of many medications.


Allergic Reactions

As with most drugs, some people can have an allergic reaction after taking Rybelsus. However, it’s not known how often allergic reactions occur with Rybelsus.

Symptoms of a mild allergic reaction can include: skin rash, itchiness and flushing (warmth and redness in your skin).

A more severe allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include: swelling under your skin (typically in your eyelids, lips, hands, or feet), swelling of your tongue, mouth, or throat and trouble breathing or speaking.

Call your doctor right away if you have a severe allergic reaction to Rybelsus. Call 911 if your symptoms feel life threatening or if you think you’re having a medical emergency.

Missed Dose

If you miss a dose of Rybelsus, wait until the next day to take your regularly scheduled dose. Don’t double up on doses to make up for the dose you missed.

To help make sure that you don’t miss a dose, try setting a reminder on your phone. A medication timer may be useful, too.


Pregnant women should Rybelsus only when clearly necessary. Consult your doctor immediately if you are planning a pregnancy, becoming pregnant, or think you might be pregnant about the risks and benefits of using this medication during pregnancy. Pregnant women are advised to stop taking this medication 2 months before conception.

Diabetes may worsen or be caused by pregnancy. You should discuss your diabetes management plan with your doctor. While you are pregnant, your doctor may adjust your diabetes treatment (such as your diet and medication).

Breast milk is not known to pass into this medication. Ask your doctor before breastfeeding.


Rybelsus blue caps contain a drying agent that helps keep the tablets dry, so Rybelsus can be preserved. Patients should keep their tablets in the Rybelsus bottle with the blue cap whenever they are not taking a tablet.

Light and moisture must be kept away from the original container while 68°F-77°F (20°C-25°C) is the recommended room temperature. Bathroom storage is not recommended. Make sure children and pets are not exposed to medications.

Unless instructed to do so, do not flush medications down the toilet or pour them into a drain. When the medication has expired or is no longer needed, properly dispose of it. Talk to your pharmacist or local waste disposal company.

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