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Starting at $158.99
On November 8, 2023, Eli Lilly and Company’s obesity treatment Zepbound™ was approved by the U.S. Food and Drug Administration (FDA). It is projected to work better compared to other weight loss drugs on the market.
Zepbound has a unique mechanism of action that sets it apart from other weight-loss medications. It activates two hormone receptors in the body called GIP and GLP-1 receptors. GLP-1 is a hormone that helps regulate appetite and food intake. Based on preliminary lab studies, GIP is another hormone that may further reduce food cravings and calorie consumption when combined with GLP-1. It is designed to supplement diet and exercise and helps with chronic weight management.
Inactive ingredients include sodium chloride and sodium phosphate dibasic heptahydrate. Sodium hydroxide solution or hydrochloric acid solution may have been used to adjust pH. Water for injection is also added.
It is used to treat certain conditions, specifically for adults with obesity (meaning severely overweight) or who are overweight, and for those who have at least one of the following weight-related medical problems:
Many insurance componies do not cover glp-1 medications such as Zepbound.
15mg (maximum dose)
A Zepbound injection is done under the skin of your stomach (abdomen), thigh, or upper arm.
There is a possibility that you will experience side effects after your first shot. It is common for patients to experience nausea, diarrhea, vomiting, constipation, stomach pain, indigestion, injection site reactions, feeling tired, allergic reactions, belching, hair loss, and heartburn after taking Zepbound
Zepbound was approved for chronic weight management by the FDA on November 8th, 2023.
After you start taking Zepbound, it takes a few weeks before you begin to notice changes in your appetite and sometimes a few weeks more before you start losing weight. The medication begins working on a cellular level relatively quickly.
It is possible to develop serious side effects from Zepbound, including kidney failure (kidney damage).
The clinical studies of Zepbound have reported that hair loss is a common side effect. Zepbound caused hair loss in 4% to 5% of users, while a placebo caused hair loss in 1% of users.
Some people may experience depression or suicidal thoughts when taking Zepbound. In the event of depression or suicidal thoughts, a physician should be contacted immediately.
As with any injection, a small amount of blood may arise from the injection site. If there is more than a small amount, cover up the wound and proceed to the nearest health facility.
Right after use, dispose of your used pen in an FDA-cleared sharps disposal container. You should not throw away (dispose of) pens in your household garbage.
Zepbound™ is injected under the skin. The medication is slowly absorbed compared to intravenous injections but much faster than oral medication.
As a GLP-1 agonist, Zepbound™ helps lower blood sugar levels and promote weight loss. It suppresses the appetite and alters the absorption that happens in the stomach. It slows the movement of food from the stomach to the small intestine, which allows patients to feel full for long periods.
Zepbound™ is expected to be a long-term treatment. Results will not happen immediately, but the effects can be dramatic. It is important to note that this medication should be used alongside proper diet and exercise to maximize desired results.
Individual results vary per patient. During the clinical trials, patients who have taken a 5mg dose of Zepbound™ weekly after 72 weeks have lost 35 lbs. on average. Meanwhile, patients who were given a placebo lost 5.3 lbs. around the same time. As a result of the trials, those who took higher doses of Zepbound™ lost more weight:
Average Weight Loss After 72 Weeks
|48. 9 lbs.
Those who participated in the trials lost 21% of their body weight. Subjects who did not have diabetes and were given 15 mg per week lost 18% while those with diabetes lost 12%.
Zepbound™ comes in a single-use injection pen that is subcutaneously injection. Each pen is a single dose. The injection sites can either be on the upper arm, abdomen, or thigh. Rotate to a different injection site for each dose taken. It can be administered at any time of the day, with or without a meal.
Patients should remember to take their injection dose. If a dose is missed, inject the missed dose as soon as possible. Then continue with the regular scheduled doses. Zepbound™ is recommended to be injected at least three days apart.
If a patient has injected too much Zepbound™, they should notify their doctor right away or call America’s Poison Centers at 800-222-1222. If the symptoms are severe and require emergency medical treatment, call 911 or head to the nearest emergency room.
The use of Zepbound™ requires a prescription from a doctor. As of today, there is no generic counterpart available.
Remove Zepbound™ from the refrigerator. Check if the pen is not frozen, cloudy, or has particles. It should be colorless or slightly yellow. Air bubbles may be observed in the solution, but it is normal. Also, check if the pen is the correct dose and if it is not expired.
Before injecting, keep your hands clean by washing. Once an injection site has been chosen, do not unlock the pen until the clear base is on the skin and ready to inject. Pull the gray cap off and discard it right away. Do not replace the cap or touch the needle.
Place the base flat on the skin of the injection site and unlock it by turning the lock ring. Press and hold the purple button for ten seconds. Listen for the first click which indicates the injection has started and then a second click which means that the injection is completed.
After the injection process, place the used pen in a sharps disposal container. Do not simply discard it in the household garbage bin.
With any drug comes side effects, which is normal. Zepbound™ is not exempt from this. Patients should always consult with their doctor about their susceptibility to side effects when it comes to using new medication. Some patients may experience mild or serious side effects when using this medication.
Patients who are prescribed Zepbound™ may experience the following:
There is also a risk for more serious side effects such as:
If a patient experiences these severe symptoms, seek medical attention, or call 911 immediately.
The list above may not be a complete list of side effects that could occur with the use of this medication. Check the packaging for warnings of other side effects. Patients may report experienced side effects to the FDA at 1-800-FDA-1088.
Zepbound™ is not recommended for patients with a family history of thyroid cancer (MTC). Patients should let their doctors know if they notice any lumps or swelling in the neck, trouble swallowing, hoarseness, or shortness of breath.
The risk of thyroid cancer was observed during animal studies of the medication. However, these studies do not always reflect the same results as humans.
It is important that patients discuss with their doctor all the medications and supplements they are currently using before being prescribed Zepbound™. Some drugs that may interact with Zepbound™ and it is not recommended to co-administer this medication with other products with the same active ingredient. This increases the risk of hypoglycemia.
Zepbound™ may interact with simultaneously administered insulin or oral medications, as well as oral hormonal contraceptives. This medication can make oral contraceptives less effective. Those who are taking birth control pills are advised to switch to non-oral contraceptives.
As for other weight management products, it has not been proven the safety and effectiveness of Zepbound™ with over-the-counter weight loss drugs and herbal supplements.
Consumption of alcohol is likely safe while prescribed with Zepbound™. For safety and peace of mind, talk to your doctor about drinking alcohol while on this medication.
The dosage of Zepbound™ depends on the doctor’s prescription. It is based on how well the patient’s condition responds to the drug or any risks to side effects.
Zepbound™ is available in six doses:
The recommended starting dose of the medication is 2.5 mg. You will take this dose for the first 4 weeks. After 4 weeks, your doctor will increase the dose to 5 mg. You will take the 5 mg dose for another 4 weeks. At that point, your doctor will determine if the 5 mg dose should be continued or if an increase is needed.
If an increase is necessary, the dose can be raised by increments of 2.5 mg, but doses should not be increased more frequently than every 4 weeks. This gradual increase allows your body to adjust to the medication and reduces the risk of side effects. The goal is to find the lowest effective dose that provides the desired results for you. Your doctor will monitor your progress and make dose adjustments as needed over time.
With the approval of Zepbound™, competition between pharmaceutical companies will force the costs of weight loss medications down. As of this writing, the price of Zepbound™ is listed between $1000-$1,060 for all six doses.
Individuals with insurance that cover Zepbound™ may pay as low as $25 for a 1–3-month prescription. Others who are insured but the coverage does not include this specific medication may pay as low as $550 for a 1-month prescription. Patients may contact their insurance providers to see if Zepbound™ is included in their coverage.
Insulin Outlet offers Zepbound™ for a fraction of the price. If this your first time ordering from Insulin Outlet, be sure to use the discount code welcome10 at checkout.
This medication is also not recommended for individuals who are pregnant and breastfeeding. Zepbound™ is a weight loss medication and during pregnancy, it is not recommended to lose weight. However, it is still unknown if Zepbound™ can harm the unborn baby or if the medication could pass through breast milk. Patients who are using Zepbound™ but have become pregnant should consult their doctor right away.
Store Zepbound™ in a refrigerator at 36°F or 46°F. Do not freeze this medication and do not use it when it is frozen. If not in use, keep it inside its packaging to avoid light exposure.
Zepbound™ may be stored at room temperature for up to 21 days. If so, do not place the medication in a refrigerator after the 21-day mark. Discard the medication if it is not used within 21 days after taking it out of the refrigerator.
Zepbound™ pens have glass parts and must be handled carefully. Make sure that it is out of reach of children.