Dupixent (Dupilumab)

There isn’t a specific Dupixent black box warning, but there are warnings about eye problems like conjunctivitis and keratitis. These conditions are more likely in those who have eczema. This medication increases that risk even more. If you have any eye problems while taking Dupixent, let your doctor know.

There are many Dupixent precautions to watch out for. When you take this medication, part of Dupixent safety is to be monitored for allergic reactions. Make sure to talk to your doctor about any pre-existing conditions you have before you take this medication. Talk to your healthcare provider if you’re unsure whether you should take it.

There’s a risk of a hypersensitivity reaction. These can include a rash, anaphylaxis, urticaria, and other reactions. If you find that you’re allergic to this medication, don’t take it. If you have a reaction, talk to your doctor right away or get emergency help if needed.

This medication can also raise your risk of eosinophilic conditions. If you get nerve pain in your feet or hands, a rash, or shortness of breath, call your doctor right away. It’s also possible to make your joint swelling or pain worse while taking Dupixent or to cause new cases of them. If you happen to have a parasitic infection, you may not be able to take this medication. Don’t take any live vaccines while taking Dupixent.

Administering Dupixent safely is important every time. If you aren’t sure how to use Dupixent, talk to your doctor.

To inject Dupixent, there are several steps to take. These Dupixent injection instructions can help.

• Get together some gauze or a cotton ball, an alcohol wipe, a container for sharps disposal, and one prefilled syringe of Dupixent. Look at the pen to make sure it isn’t damaged.
• Lay it down on a flat surface to let it get to room temperature. Allow it to lay flat for about 45 minutes before you use it. Wash your hands with soap and choose a site to inject the pen. This can be in the thighs, abdomen, or upper arms.
• Next, use the alcohol wipe to clean the injection site. Let your skin get completely dry.
• Take the cap off the injection pen.
• Pinch the skin at the injection site.
• Hold the pen at the injection site so that you are able to see the window on it, pressing it firmly into the skin until you can’t see the needle cover. The pen will click when the injection starts.
• As the window starts to turn yellow, watch it until it’s completely yellow and the pen clicks a second time.
• Then, count to five and pull straight upward to remove the pen.
• If there is blood, use the gauze or cotton ball to clean it.
• Dispose of the pen in a sharps container.

Many people wonder about how Dupixent works and the specific Dupixent mechanism of action. This drug works by targeting a specific protein that helps to create inflammation and binding to it. When it does this, it can keep the protein from signaling and therefore inhibit some of the inflammation that would have happened. This reduction in inflammation means that both eczema and asthma can be reduced as the immune system is inhibited from attacking the body. It calms the immune system when it’s overactive rather than suppressing the immune system.

Some of the benefits of Dupixent include its effectiveness in treating several different conditions. It can be taken for asthma, eczema, and several other conditions. Taking Dupixent for chronic conditions can help people not to have to rely on steroids, as Dupixent is a biologic.

There are many Dupixent side effects that are possible. The side effects include:

• Eyelid inflammation
• Higher risk of mouth cold sores for those with herpes
• Pink eye
• Injection site reactions like swelling and pain
• Keratitis
• Toothache
• Stomach inflammation
• High count of white blood cells
• Insomnia
• Throat soreness or pain
• Muscle pain
• Upper respiratory infection
• Throat and nose inflammation
• Joint pain
• Dizziness

There are a few possible Dupixent drug interactions. Sometimes, Dupixent and other medications simply don’t mix well, and often these medications can’t be used together. Some of the medications that can interact badly with Dupixent include:

• Warfarin
• Lithium
• Live vaccines

For patients who need Dupixent alternatives, there are other treatments for eczema or asthma. Some of these Dupixent alternatives include:

• Elidel
• Rinvoq
• Dupilumab
• Topical mometasone
• Topical triamcinolone

Patients wondering how to take Dupixent need to speak to their doctors about the best way for them to take it. There are many different strengths of this drug available, and the Dupixent dosage that you’re prescribed will depend on why you’re taking it and how well it works for you. The prefilled pens come in 300 mg/2 mL and 200 mg/1.14 mL. This medication is administered with a prefilled syringe that contains the solution.

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