Glumetza (Metformin Hydrochloride)

Glumetza can cause lactic acidosis, a rare but serious metabolic complication that can be fatal. Patients should be monitored for renal function before and during treatment, as the risk of lactic acidosis increases with renal impairment. Symptoms of lactic acidosis, such as malaise, muscle pain, and respiratory distress, require immediate medical attention.

The following conditions should prevent you from using Glumetza:

● A chronic kidney disease; or

● diabetic/insulin ketoacidosis or metabolic acidosis (call your doctor for treatment).

You may need to temporarily stop taking Glumetza if you need surgery or any type of x-ray or CT scan that uses a dye that is injected into your veins. If you are using this medication, inform your caregivers in advance.

You should tell your doctor if you have ever experienced any of the following:

● Kidney disease (you might need to get a kidney test before taking this medicine);

● A high level of ketones in your blood or urine;

● Having a heart condition, congestive heart failure;

● An underlying liver disease;

● If you also take insulin or other oral diabetes medications (such as Jardiance).

A dangerous buildup of lactic acid in your blood is called lactic acidosis. You are more likely to develop this condition if you have other medical conditions, a serious infection, chronic alcoholism, or if you are over 65. Consult your healthcare professional about your risk.

Children younger than 10 should not be given Glumetza. Young people younger than 18 are not permitted to use some forms of metformin.

Be sure to follow all instructions on your prescription label and to read all medication guides or instructions. It is possible that your doctor will occasionally change your dose. Make sure you follow the directions exactly when taking the medicine.

If your doctor recommends otherwise, take Glumetza with a meal. It is possible to take metformin only once daily with your evening meal in some forms. Be sure to follow the instructions given to you by your doctor.

Extended-release tablets should not be crushed, chewed, or broken. It should be swallowed whole.

Be careful when measuring liquid medicine. The medicine dose-measuring device (not a kitchen spoon) should be used, or the dosing syringe provided.

Be sure to shake the oral suspension (liquid) before measuring a dose. Make sure you use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

There are some tablets that have a shell that cannot be absorbed or melted by the body. Your stool may contain some of this shell. As a result, the medicine will not be less effective.

Your doctor may have you take extra vitamin B12 while you are taking Glumetza. Take only the amount of vitamin B12 that your doctor has prescribed.

You may have symptoms including nausea, vomiting, stomach upset, diarrhea, weakness, or a metallic taste in your mouth. Immediately tell your doctor if you experience one or more of these effects. Your doctor should be informed if your stomach symptoms return later (after taking the same dose for several days or weeks). If you experience stomach symptoms following treatment, you may have lactic acidosis.

There is a possibility that you will find an empty tablet shell in your stool. Due to the fact that the medication has already been absorbed into your body, this effect is harmless.

Despite any potential risks, your doctor has prescribed this medication based on its benefits. The medication usually has no serious side effects.

Hypoglycemia (low blood sugar) is usually not caused by metformin. With this drug and other diabetes medications, low blood sugar may occur. If your other diabetes medications need to be adjusted, speak to your doctor or pharmacist.

In addition to sweating, shaking, a rapid heartbeat, hunger, blurred vision, dizziness, or tingling fingers or toes, low blood sugar can cause headaches and fatigue. For treating low blood sugar, glucose tablets or gel are a good habit to keep on hand. Consume table sugar, honey, candy, or fruit juice if you don’t have these reliable forms of glucose, or drink non-diet soda or fruit juice if you don’t have them. Contact your doctor right away if you experience a reaction. You are more likely to have low blood sugar if you drink a lot of alcohol, exercise excessively, or consume too few calories. Eat regular meals and avoid skipping meals to prevent low blood sugar. In case of missing a meal, talk to your doctor.

In addition to thirst, increased urination, confusion, drowsiness, flushing, rapid breathing, and fruity breath odor, hyperglycemia can be characterized by high blood sugar (hyperglycemia). Inform your doctor as soon as possible if you experience these symptoms. If you are taking diabetes medication(s), your doctor may have to adjust them.

This drug rarely causes severe allergic reactions. If you experience any of the following symptoms of a serious allergic reaction, seek medical attention immediately: rash, itching/swelling (especially of the face, tongue, or throat), severe dizziness, trouble breathing.

The following is not a complete list of possible side effects. Contact your doctor or pharmacist if you notice any other effects not listed above.

Glumetza may occasionally cause lactic acidosis, a serious side effect. Your blood becomes lactic acidic due to lactic acid buildup. There can be serious damage caused by this build-up. Lactic acidosis caused by Glumetza is rare and occurs mainly in people whose kidneys are not functioning normally. Glumetza has been reported to cause lactic acidosis in about one in 33,000 patients. Although rare, if lactic acidosis does occur, it can be fatal in up to half the people who develop it.

When you take Glumetza, it is also important for your liver to function normally. Lactic acid is removed from your blood by your liver.

Glumetza should not be used if you have kidney or liver problems. If you have symptoms of lactic acidosis, stop taking Glumetza and call your doctor immediately. A hospital should be consulted if you have lactic acidosis, as it is a medical emergency.

Lactic acidosis symptoms include:

● Having a feeling of weakness, fatigue, or discomfort

● Muscle pain that is unusual

● Breathing problems

● Stomach discomfort that is unusual or unexpected

● Cold feeling

● Dizziness or lightheadedness

● A sudden slowing or irregular heartbeat

Glumetza should be stopped immediately if your medical condition suddenly changes. You may be experiencing lactic acidosis or another serious side effect.

You may develop lactic acidosis if you take carbonic anhydrase inhibitors such as Topamax (topiramate) and Diamox (acetazolamide).

Other interactions with Glumetza include:

● Lasix (furosemide)

● Procardia (nifedipine)

● Tagamet (cimetidine)

It is possible for some drugs to increase blood sugar levels. Blood sugar control can be affected when using Glumetza. Among these drugs are:

● Calcium channel blockers

● Corticosteroids

● Diuretics (including but not limited to thiazide)

● Estrogens

● Hydra (isoniazid)

● Niacor or Niaspan (nicotinic acid)

● Oral contraceptives

● Phenothiazines

● Dilantin (phenytoin)

● Sympathomimetics

● Thyroid drugs (such as Armour Thyroid)

These drugs should be used with caution along with Glumetza. Make sure you check with your healthcare provider before taking any new medicines, especially those that could affect your blood sugar levels.

Ensure that your healthcare provider is aware of all your medications, including prescriptions, nonprescriptions, vitamins, and herbal supplements. There may be interactions between Glumetza and other medicines, and Glumetza may have an effect on other medicines.

You should take the medicine as soon as possible, but skip the missed dose if it is almost time for your next dose. Two doses should not be taken at the same time.

In the case of an overdose resulting in serious symptoms such as passing out or trouble breathing, call 911 immediately. In any case, you should contact a poison control center as soon as possible. US residents can contact their local poison control center at 1-800-222-1222. There are several symptoms of overdose, including extreme drowsiness, nausea/vomiting/diarrhea, rapid breathing, and slow/irregular heartbeat.

Drinking alcohol while taking Glumetza is not recommended. You shouldn’t binge drink for short periods of time or drink a lot of alcohol regularly. Lactic acidosis can be caused by alcohol.

The use of Glumetza during pregnancy should be limited to those prescribed by your doctor. It is possible that your doctor will instruct you to use insulin instead of this product while you are pregnant. Menstrual cycle changes (promote ovulation) and increased risk of pregnancy can be caused by this medication. Consult your doctor about the use of reliable birth control. A small amount of this medication passes into breast milk. Breastfeeding should be discussed with your doctor.

Active Ingredient: metformin hydrochloride

Inactive Ingredients: dye, hypromellose, magnesium stearate, microcrystalline cellulose and polyethylene oxide.

In order to preserve its effectiveness, this medication should be stored at room temperature between 68°F and 77°F (20°C and 25°C).

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