Hulio (Adalimumab)

Hulio carries the risk of serious infections, including tuberculosis, bacterial sepsis, invasive fungal infections, and infections due to other opportunistic pathogens. Patients need to be tested for latent TB before and during therapy. The medication may also elevate the risk of malignancies, such as lymphoma and other cancers, particularly in pediatric patients.

You can contract infections more easily, even serious or fatal ones. Symptoms of influenza, cough, night sweats, neck stiffness, confusion, or vision problems should be reported to your doctor. A tuberculosis or other infection test should be conducted before you use Hulio.

After you stop taking Hulio, you may develop hepatitis B again, or it may get worse. Your doctor should be contacted if you are feeling unwell and are experiencing pain in your right upper stomach, vomiting, loss of appetite, or yellowing of your skin or eyes. For several months, you may need liver function tests.

Before taking Hulio, tell your doctor if you have a fever, chills, cough, body aches, tiredness, open sores or wounds, diarrhea, stomach cramps, weight loss, or painful urination.

If you have had or been exposed to tuberculosis or fungal infection, or if you have traveled recently or plan to travel, tell your doctor. Travel may expose you to infections that are more common in certain parts of the world.

You should tell your doctor if you have or have ever had:

• You have tuberculosis (or anyone in your household has tuberculosis);
• A chronic or active infection;
• A cancerous tumor;
• A recurrence of hepatitis B (Hulio can exacerbate hepatitis B);
• Diabetes;
• Insufficiency of the heart;
• Multiple sclerosis or Guillain-Barré syndrome, or any numbness or tingling;
• Latex or rubber allergies;
• A major surgery is scheduled, or
• Any vaccine you have recently received or are expected to receive.

Before you start using Hulio, make sure you are up-to-date on all your vaccines.

An injection of Hulio is given under the skin. This medicine will be taught to you by a healthcare provider so you can use it on your own. Ensure that you only inject the same area once.

Only prepare an injection when you are ready to administer it. Please get in touch with us if the medicine looks cloudy, changes colors, or has particles. If you need help understanding how to use an injection, feel free to contact us and we can set you up with one of our pharmacists.

Children and teenagers are given doses based on their weight. If your child gains or loses weight, the dose may change.

You can get infections more easily, even serious or fatal infections. There will be much medical testing required of you.

A tuberculosis or other infection test will be conducted before you use Hulio. This medicine will be tested on your blood before and during treatment.

Hulio may worsen hepatitis B if you’ve previously had it or come back during treatment. You may need liver function tests while taking this medicine and for some time after stopping it.

Serious Side Effects

As your body gets used to the medication, the following side effects may disappear. In case these symptoms continue or worsen, notify your healthcare provider immediately. If you experience any of these symptoms, you should contact your healthcare provider right away.

• A severe infection can cause fever, cough, weight loss, muscle aches, dark urine, chills, vomiting, and nausea.
• If you experience a severe allergic reaction, you may notice a rash, trouble breathing, or swelling of your face, eyes, lips, mouth, or hives.
• Fever, easy bruising or bleeding, and pale skin are signs of low blood cell counts.
• Symptoms of heart failure include shortness of breath, swelling in the legs, ankles, or feet, irregular heartbeat, tiredness, and rapid weight gain.
• Symptoms of liver problems include fatigue, vomiting, yellow skin or whites of the eyes, and stomach discomfort.

Common Side Effects

• Reaction at the injection site
• Infection of the upper respiratory tract
• Having a headache
• Rash
• Symptoms of sinus inflammation
• Injuries caused by accidents
• Symptoms of nausea
• Infection of the urinary tract (UTI) or bladder

Symptoms of other side effects

• A high cholesterol level (be sure to mention to your doctor if you are taking cholesterol medication such as Lipitor and Crestor).
• Blood pressure is high
• Pain in the back
• Pain in the stomach
• Loss of hair
• Urine with blood
• Symptoms of the flu

There is a risk of drug interactions with Hulio (adalimumab) when certain medications are taken. Tell your doctor if you are taking other medications or supplements (including prescription and over-the-counter medications, vitamins, and dietary supplements). There may be interactions between Hulio (adalimumab) and other drugs not listed below. Each medication is listed only by its generic name below.

This medicine should not be used with any of the following medicines, but it may be necessary in some cases. The dose or frequency of either or both of the medicines may need to be adjusted if both medicines are prescribed at the same time.

• Abatacept
• Vaccine against Adenovirus
• Anakinra
• Live Bacillus of Calmette and Guerin Vaccine
• Live Cholera Vaccine
• Live Dengue Tetravalent Vaccine
• Infliximab
• Live Influenza Virus Vaccine
• Live Measles Virus Vaccine
• Live Mumps Virus Vaccine
• Live Poliovirus Vaccine
• Rilonacept
• Live Rotavirus Vaccine
• Live Rubella Virus Vaccine
• Vaccine against smallpox
• Tofacitinib
• Live Typhoid Vaccine
• Live Varicella Virus Vaccine
• Vaccine against yellow fever
• Live Zoster Vaccine

Adults

• The typical starting dose for rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis is 40 mg injected under the skin every other week.
• It is typical to inject 160 mg of the medication under the skin on Day 1, 80 mg on Day 15, and 40 mg every other week starting on Day 29 for Crohn’s disease and ulcerative colitis.
• For plaque psoriasis, 80 mg is typically injected under the skin on the first day, followed by 40 mg every other week afterward.
• A typical dosage is 160 mg injected under the skin on Day 1, 80 mg on Day 15, then 40 mg every week, or 80 mg every other week starting on Day 29.

Children

• Your child’s body weight will determine the dose for juvenile idiopathic arthritis and Crohn’s disease. Once every two weeks, it will be injected under the skin.

In case of pregnancy or if you plan to become pregnant, consult your doctor before using Hulio; its effects on a fetus are not known. As a result of its ability to inhibit TNFa, adalimumab products such as Hulio may affect the immune response of the newborn and infant exposed to adalimumab during pregnancy. Adalimumab levels are elevated in infants, but their clinical significance is unknown. Breastfeeding should be discussed with your doctor.

In America, Hulio costs around $6,935 for a supply of two kits, depending on the pharmacy. All prices quoted are for cash-paying customers and are not valid with insurance plans.

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