Hyrimoz (Adalimumab)

Hyrimoz may cause serious infections, including tuberculosis, bacterial sepsis, invasive fungal infections, and infections due to other opportunistic pathogens. Patients should be tested for latent TB before and during treatment. The medication may also increase the risk of malignancies, including lymphoma and other cancers, especially in pediatric patients.

It is essential to weigh the risks of taking a medicine against its benefits before using it. Your doctor and you will make this decision together. The following considerations should be taken into account when using this medicine:

Allergies

Any unusual or allergic reaction to this or any other medicine should be reported to your doctor. You should also tell your health care professional if you have any other allergies, such as food allergies, dye allergies, preservative allergies, or animal allergies. Read the ingredients on non-prescription products carefully.

Pediatric

Adalimumab-adaz injection has not been shown to pose pediatric-specific problems that would limit its effectiveness in treating juvenile idiopathic arthritis in children two years and older or Crohn’s disease in children six years and older, according to appropriate studies conducted to date. Children younger than two years of age or weighing less than 10 kilograms (kg) have not been evaluated for safety or efficacy in juvenile idiopathic arthritis, Crohn’s disease, or other conditions.

Geriatric

Adalimumab-adaz injection has not been shown to cause geriatric-specific problems in adalimumab-adaz studies performed to date. Patients receiving this medicine should be cautious since this medicine may cause severe infections and cancer more often in the elderly.

Breast Feeding

Using this medication during breastfeeding has not been adequately studied in women, before taking this medication while breastfeeding, weigh its potential benefits and risks.

Usually given every two weeks, Hyrimoz is injected under the skin as a solution. Depending on the condition to be treated, the dose and frequency of injections will vary, and the dose for a child will be based on their weight. If their doctor deems it appropriate, patients or their caregivers may inject Hyrimoz after receiving training.

Treatment with Hyrimoz must be started and supervised by a doctor experienced in treating the diseases for which Hyrimoz is prescribed. Doctors who have experience using Hyrimoz should also provide advice to eye specialists treating uveitis.

Hyrimoz package leaflets are available upon request, or you can contact your doctor or contact us to set up a free pharmacist consultation.

Infection (including nose, throat, and sinus infections), injection-site reactions (redness, itching, bleeding, pain or swelling), headache, and muscle and bone pain are the most common side effects with adalimumab (more than 1 patient in 10).

Several cases of serious infections and blood cancers have been reported in patients using adalimumab, along with other medicines of its class.

It is also possible for the bone marrow to fail to produce blood cells, nerves to malfunction, lupus (a condition in which the immune system attacks the body’s own tissues, causing inflammation and organ damage) and Stevens-Johnson syndrome (a life-threatening reaction characterized by flu-like symptoms and a painful rash on the skin, mouth, eyes, and genitals).

Hyrimoz is not recommended for patients with active tuberculosis or other severe infections, or in patients with moderate to severe heart failure.

Even if an interaction might occur between two different medicines, there are some cases in which they may be used together, even if they cannot be combined. Depending on the situation, your doctor may need to change the dose or take other precautions. The following medicines should be discussed with your healthcare professional before you begin taking this medicine. It is not necessarily an all-inclusive list but has been compiled based on potential significance.

It is usually not recommended to use this medicine with any of the following medications, but it may be necessary in some cases. If both medicines are prescribed, your doctor may change the dose or frequency of one or both.

• Abatacept
• Vaccine against Adenovirus
• Anakinra
• Anifrolumab-fnia
• Vaccine against Bacillus of Calmette and Guerin, live
• Baricitinib
• Live Cholera Vaccine
• Cyclosporine
• Live Dengue Tetravalent Vaccine
• Live Ebola Zaire Vaccine
• Infliximab
• Live Influenza Virus Vaccine
• Live Measles Virus Vaccine
• Methotrexate
• Live Mumps Virus Vaccine
• Live Poliovirus Vaccine
• Rilonacept
• Live Rotavirus Vaccine
• Live Rubella Virus Vaccine
• Smallpox Monkeypox Vaccine, Live Non-Replicating
• Smallpox Vaccine
• Theophylline
• Live Typhoid Vaccine
• Live Varicella Virus Vaccine
• Warfarin
• Yellow Fever Vaccine
• Live Zoster Vaccine

According to studies, giving Hyrimoz produces similar levels of the active substance in the body as giving Humira.

Hyrimoz was also found to be as effective as Humira in a study involving 465 patients with moderate or severe plaque psoriasis. Following 16 weeks of treatment, 68% of Hyrimoz patients had at least a 75% reduction in symptoms and 63% of Humira patients had at least a 75% reduction.

It is not necessary to repeat all the studies on adalimumab performed on Humira for Hyrimoz since it is a biosimilar medicine.

Children should not be allowed to access this product.

Keeping outdated or no longer needed medicine is not a good idea.

Don’t throw away any medicine you don’t use without asking your healthcare provider how to do so.

The product should be stored in the refrigerator. Do not freeze.

It should be kept in its original container. Keep away from light. It should not be used if it has been frozen or thawed. Up to 14 days can be stored at room temperature if necessary (e.g., while traveling). Store it at a temperature that is not too cold or too hot. The medicine should be thrown away after 14 days if it has not been used.

Used syringes should be disposed of in a hard, closed container so needles cannot penetrate it. Pets and children should not be allowed to play with this container.

Hyrimoz has become rather popular in replacing Humira due to its cost. Humira is one of the most expensive medications in the United States. However, Hyrimoz treats different conditions than Humira.

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