Mestinon SR (Pyridostigmine Bromide)

Mestinon SR can cause cholinergic crisis, which is characterized by excessive salivation, sweating, muscle cramps, and weakness, and may be life-threatening. Patients should be closely monitored for signs of overmedication and dosage adjustments should be made accordingly.

Do not take this medication if you have an allergy to Pyridostigmine or any ingredients in this Mestinon.

Speak to your doctor about any of your past or existing medical conditions, especially if you have: asthma or COPD, intestinal/stomach blockage, kidney or lung disease, urinary blockage, slow/irregular heartbeat or diabetes.

Notify your doctor of any other medications, supplements, herbal medicines, or vitamins you are currently taking.

Consult your doctor if you are pregnant or breastfeeding.

Do not use this medication if you have bladder or bowel obstruction.

Since this medication can cause blurred vision, do not drive or operate any heavy machinery after taking it. Please do not drink alcohol after taking Mestinon as it can increase specific side effects of Pyridostigmine.

This medication is not approved to be taken by anyone under the age of 18.

In addition to blurred vision and headaches, Mestinon can cause vomiting, rash, abdominal pain, diarrhea, and nausea.

The medication can cause significant side effects such as severe muscle weakness, slurred speech, vision difficulties, and worsening or no improvement in myasthenia gravis. Get in touch with your pharmacist, doctor, or visit a health facility immediately if you experience any serious side effects.

Each individual may react differently to a treatment. Talk to your doctor or pharmacist if you think this medication is causing side effects (including those described here or others). Your physician can help you determine whether or not the medication is the cause of the problem.

Although the failure of patients to show clinical improvement may reflect under dosage, it can also be indicative of overdosage. As is true of all cholinergic drugs, overdosage of Mestinon (pyridostigmine) may result in cholinergic crisis, a state characterized by increasing muscle weakness which, through the involvement of the muscles of respiration, may lead to death. Myasthenic crisis due to an increase in the severity of the disease is also accompanied by extreme muscle weakness and thus may be difficult to distinguish from the cholinergic crisis on a symptomatic basis. Such differentiation is significant since increases in doses of Mestinon (pyridostigmine) or other drugs of this class in the presence of cholinergic crisis or a refractory or “insensitive” state could have grave consequences.

Mestinen (pyridostigmine) is contraindicated in patients with mechanical intestinal obstruction or urinary obstruction, and patients with bronchial asthma should be cautious when taking it. As discussed below, atropine should be used with caution to counteract side effects.

Pregnant or lactating women have not been proven safe when taking Mestinon (pyridostigmine). The potential benefits and risks of using Mestinon (pyridostigmine) during pregnancy must be weighed against the potential hazards to the mother and child.

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