Ozempic Semaglutide Injection (4mg/3mL)

Ozempic carries a risk of thyroid C-cell tumors, including medullary thyroid carcinoma (MTC). Patients with a personal or family history of MTC or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) should not use this medication. Regular monitoring for symptoms of thyroid tumors, such as a lump in the neck or hoarseness, is recommended.

Ozempic is not meant to be used by patients with type 1 diabetes.

Before taking Ozempic, inform your doctor about your complete health history. Be sure to let them know of any insulin pens or vials that you are taking. Ozempic should not be prescribed if you have pre-existing issues such as an allergy to GLP-1 agonists, caution is advised if you’ve had diabetic retinopathy in the past, or have kidney disease, or a history of pancreatitis. If you have severe kidney issues, your doctor may not prescribe Ozempic.

Regardless of whether the needle has been changed, Ozempic pens should not be shared. Sharing can lead to serious infections.

A boxed warning on Ozempic warns patients and doctors about increased Thyroid C-cell Tumor risk. Consult your doctor for more information.

You should wear identification such as a bracelet or necklace to show others that you have diabetes and that you are taking medication to control your blood sugar.

Kidney Function

In rare cases, Semaglutide (Ozempic) may cause kidney failure/injury. Your doctor should be able to help you determine if special monitoring is needed if you have kidney disease or reduced kidney function.

Heart Problems

Ozempic may increase your heart rate. Speak to your doctor if you have an abnormal heart condition (i.e., heart block, arrhythmia) or heart disease. They may choose to adjust the dosage of medications and require close monitoring.

Hypoglycemia (low blood sugar)

Patients currently taking a sulfonylurea (i.e., gliclazide, glyburide) or insulin along with Ozempic may be at risk of hypoglycemia. If you are experiencing symptoms of hypoglycemia such as increased heart rate, headache, cold sweat, nervousness, numbness or tingling of tongue/lips, lightheadedness, confusion, hunger, or weakness, consult your doctor. Your doctor may choose to adjust the dosage of medications you are taking.

Pancreatitis (inflammation of the pancreas)

Pancreatitis may be caused by Ozempic. Pancreatitis typically presents with severe abdominal pain. As Ozempic may be contraindicated, tell your doctor if you have had pancreatitis before.

Thyroid Cancer

The use of this medication should be avoided by people who have had medullary thyroid cancer or have a family history of it or multiple endocrine neoplasia syndrome type 2A or 2B.

Children

The effectiveness and safety of Ozempic have not been established for children.

Ozempic should be injected subcutaneously to the abdomen, thighs, or upper arms.

If injecting in the same body region each week, patients should use a different injection site every week.

Before using Ozempic, inspect it visually. The liquid should appear clear and colorless. Ozempic should not be used if particulate matter and coloration are present.

Ozempic and insulin should be administered separately and not mixed when being used together. Ozempic and insulin can both be injected simultaneously in the same body region, but the injections should not be adjacent.

Semaglutide can be used to help with weight loss management in conjunction with a proper diet and exercise plan to maximize results.

As with most medications, Ozempic may cause common or severe side effects in patients prescribed this drug. Please speak to your doctor about your medical history, lifestyle, and medication intake in great detail before administering Ozempic.

Common Side Effects

• Nausea
• vomiting
• diarrhea
• abdominal pain
• constipation

Severe Side Effects

The inflammation of your pancreas (pancreatitis) is one of the severe side effects. Whenever you experience severe stomach pain (abdomen) that persists, with or without vomiting, stop using Ozempic and consult your healthcare provider immediately. The pain may extend down your spine as well.

Other severe-side effects may include vision changes. If you notice any changes in vision while taking Ozempic, tell your healthcare provider.

Ozempic may cause hypoglycemia. Dizziness or lightheadedness, blurred vision, anxiety, irritability, mood changes, sweating, slurred speech, hunger, confusion or drowsiness, shakiness, weakness, headache, fast heartbeat, feeling jittery, can all be signs of low blood sugar.

Diarrhea, nausea, and vomiting may cause dehydration in people with kidney problems, which may worsen their kidney problems. Drinking fluids will help to keep you hydrated and help reduce your risk of dehydration.

Ozempic may also cause severe allergic reactions. Stop using Ozempic and get medical help right away if you have any symptoms of a severe allergic reaction, including swelling of your face, lips, tongue, or throat, problems breathing or swallowing, severe rash or itching, fainting or feeling dizzy, rapid heartbeat.

The active ingredient in Ozempic is semaglutide. The inactive ingredients are disodium phosphate dihydrate, propylene glycol, phenol, and water for injection.

There is limited data on semaglutide use in pregnant women to inform a drug-associated risk for adverse developmental outcomes. 

There are clinical considerations regarding the risks of poorly controlled diabetes in pregnancy.

Based on animal reproduction studies, the fetus may have potential risks from exposure to semaglutide during pregnancy. Ozempic should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. 

In pregnant rats administered semaglutide during organogenesis, embryofetal mortality, structural abnormalities, and alterations to growth occurred at maternal exposures below 1x the maximum recommended human dose (MRHD) based on Area Under the Curve (AUC).

In rabbits and cynomolgus monkeys administered semaglutide during organogenesis, early pregnancy losses and structural abnormalities were observed below the MRHD (rabbit) and ≥5-fold the MRHD (monkey). These findings coincided with a marked maternal body weight loss in both animal species .

Breastfeeding

There is no data on the presence of semaglutide in human milk, the effects on the breastfed infant, or the effects on milk production. Semaglutide was present in the milk of lactating rats, however, due to species-specific differences in lactation physiology, the clinical relevance of this data is not clear. The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for Ozempic and any potential adverse effects on the breastfed infant from Ozempic or the underlying maternal condition.

In the event of overdose, appropriate supportive treatment should be initiated according to the patient’s clinical signs and symptoms. A prolonged period of observation and treatment for these symptoms may be necessary, taking into account the long half-life of Ozempic of approximately one week.

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