Premarin (Conjugated Estrogens)

Premarin increases the risk of endometrial cancer, stroke, deep vein thrombosis, myocardial infarction, and invasive breast cancer. Patients should be closely monitored, and the benefits and risks should be regularly reassessed. The medication should be used at the lowest effective dose for the shortest duration necessary to achieve treatment goals.

It is important that you inform your doctor or pharmacist if you have an allergy to this medication, or if you have any other allergies. There is a possibility that this product contains inactive ingredients, which can cause allergic reactions or other problems. For more information, please request to speak to one of our pharmacists.

Tell your doctor or pharmacist about your medical history before taking Premarin. This includes mentioning any of the following: vaginal bleeding of unknown cause, certain cancers (such as breast cancer, cancer of the uterus/ovaries), blood clots, stroke, heart disease (such as heart attack), liver disease, kidney disease, family medical history (especially breast lumps, cancer, blood clots), family or personal history of a certain swelling disorder (angioedema), blood clotting disorders (such as protein C or protein S deficiency), high blood pressure, diabetes, high cholesterol/triglyceride levels, obesity, lupus, underactive thyroid (hypothyroidism), mineral imbalance (low or high level of calcium in the blood), a certain hormone problem (hypoparathyroidism), uterus problems (such as fibroids, endometriosis), gallbladder disease, asthma, seizures, migraine headaches, a certain blood disorder (porphyria), mental/mood disorders (such as dementia, depression).

It is not a good idea to smoke or use tobacco. Smoking combined with estrogen increases your risk of stroke, blood clots, high blood pressure, and heart attack, especially in women over 35.

Tell your doctor if you just had surgery or will have surgery, or if you will be confined to a chair or bed for a long time (such as a long flight). In particular, if you are taking an estrogen product, these conditions increase your risk of blood clots. It may be necessary for you to stop taking this medication for a while or take special precautions.

The medication may cause blotchy, dark areas on your face and skin (melasma). This effect may be exacerbated by sunlight. Don’t spend too much time in the sun. Sunlamps and tanning booths should be avoided. When you are outdoors, wear sunscreen and protective clothing.

It is possible to develop vision problems or trouble wearing contact lenses if you are nearsighted or wear contact lenses. If you experience any of these problems, contact your eye doctor right away.

The side effects of this drug may be more severe in children. Their growth/development may be affected. Your child’s growth should be monitored periodically while taking this medication. Discuss any possible side effects with your doctor.

Before using this medication and each time you get a refill, read the Patient Information Leaflet available from your pharmacist. Ask your doctor or one of our pharmacist if you have any questions. If you would like to reach out to one of our pharmacist, feel free to contact us.

As directed by your doctor, take this medication by mouth with or without food. To prevent stomach upset, you may take it with food or right after a meal.

Taking extended-release tablets shouldn’t be crushed, chewed, or dissolved. Consequently, it can lead to side effects since the entire drug is released at once. The tablets should be swallowed whole.

Your medical condition and response to treatment determine the dosage.

For best results, take this medication regularly. Keep track of the time(s) you take it each day to help you remember to take it. Make sure you follow your dosing schedule carefully. Take this medication as directed and do not increase your dose or take it more often or for longer than recommended.

Consult your doctor if you see something that looks like a conjugated estrogen tablet in your stool.

In order to determine whether you should continue this treatment, your doctor should check your progress regularly. Have regular mammograms and self-examine your breasts monthly for lumps.

It may be necessary to stop taking this medicine for a short period of time if you need major surgery or will be on long-term bed rest. Premarin should be disclosed to any doctor or surgeon who treats you.

If your condition does not improve or worsens, contact your doctor.

The following signs of an allergic reaction to Premarin should be reported to your healthcare provider right away: hives, difficulty breathing, swelling of the face, lips, tongue, or throat.

If you experience any of the following symptoms, contact your doctor immediately:

● Heart attack symptoms – chest pain or pressure, pain spreading to your jaw or shoulder, sweating;

● Symptoms of stroke – sudden numbness or weakness, severe headaches, slurred speech, vision problems, balance problems;

● Blood clot symptoms include sudden vision loss, stabbing chest pain, coughing up blood, or leg pain or warmth;

● An increase in weight and swelling;

● Jaundice (yellowing of the skin and eyes);

● Having difficulty remembering things, being confused, or acting strangely;

● Pain in the pelvis, unusual vaginal bleeding;

● Breast lumps; or

● A high level of calcium in your blood can lead to nausea, constipation, increased thirst or urination, muscle weakness, bone pain, and fatigue.

Common Premarin side effects may include:

● Inflammation;

● Loss of hair;

● A feeling of numbness, tingling, or burning;

● A backache, leg cramps, or pain in the legs;

● Stomach pain, nausea, vomiting, bloating, gas, indigestion;

● Headache, dizziness;

● Pain in the breast; or

● You may experience vaginal itching or discharge, change in your menstrual cycle, or breakthrough bleeding.

There may be other side effects not listed here. For medical advice about side effects, contact your doctor. FDA can be contacted at 1-800-FDA-1088 if you experience side effects.

There is a possibility that drug interactions may alter how your medications work or increase your risk of serious side effects. There are not all possible drug interactions listed on this page. You should keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Your doctor must approve any changes to your medicines, including starting, stopping, or changing the dosage.

The following products may interact with this drug: aromatase inhibitors (such as anastrozole, exemestane, letrozole), fulvestrant, ospemifene, raloxifene, tamoxifen, toremifene, tranexamic acid.

Some laboratory tests (including metyrapone tests) may be affected by this medication, resulting in false results. You should inform all your doctors and laboratory personnel that you are taking this medication.

If someone has overdosed and is having serious symptoms, such as passing out or trouble breathing, call 911 immediately. Otherwise, contact a poison control center immediately. Residents of the US can contact their local poison control center at 1-800-222-1222. Overdose symptoms may include nausea, vomiting, and unusual vaginal bleeding.

Take the missed tablet if it has been less than 12 hours since you normally take Premain.

You should discard the missed tablet if more than 12 hours have passed and take the next tablet when you normally would.

Do not take a double dose to make up for the one you missed.

Ask one of our pharmacist for suggestions if you have trouble remembering when to take your medicine.

If you become pregnant while taking this drug, discontinue use immediately.

There is no oral contraceptive in this drug, nor will it restore fertility. If taking this drug, women of childbearing potential should use non-hormonal contraception.

During pregnancy, inadvertent exposure to estrogens and progestins did not cause any teratogenic or fetotoxic effects on the fetus

You should keep your tablets in the blister pack until you are ready to take them. You may not be able to keep them well if you take them out of the blister.

Tablets should be stored in a cool, dry place with a temperature below 25°C.

Premarin, or any medicine, should not be stored near a sink or in the bathroom. Keep Premarin away from cars and windowsills.

Some medicines can be destroyed by heat and dampness.

Make sure it is out of reach of children.

Store medicines in a locked cupboard at least one-and-a-half meters above the ground.

At Insulin Outlet, we ensure the safety and quality of our medications, meeting all federal legislation standards. Your order will be dispatched from a reputable licensed Canadian pharmacy, guaranteeing the highest standards of reliability and authenticity. This medication has been approved by Health Canada (Canada's FDA) and is identical to what you would receive in the US, only with Canadian labeling and packaging. We do not sell counterfeit or unauthorized medications. Our discounted medications are shipped directly from Canada to your doorstep, providing a fast and secure delivery experience. To conveniently buy Premarin online at a significant discount, place your order above or call us at 1-888-238-0872.