Trelegy Ellipta

Trelegy Ellipta is a prescription medication used for the long-term, once-daily maintenance treatment of:

• Chronic obstructive pulmonary disease (COPD): This includes chronic bronchitis, emphysema, or both, in adults.
• Asthma: In adults.

‼️Trelegy is not a rescue medication. It should not be used during an emergency, as it is a maintenance medication, not a fast-acting inhaler.

COPD

Trelegy Ellipta is a prescription medicine used to treat COPD – a chronic lung disease that includes chronic bronchitis, emphysema, or both.
Trelegy Ellipta is used to improve symptoms of COPD for better breathing and to reduce the number of flare-ups.

Asthma

The medication can also be used to prevent and control asthma symptoms, such as wheezing, for better breathing.

🗒️Worth Noting

Vilanterol, a LABA, presents potential risks when used as a single asthma treatment. However, in Trelegy Ellipta, its combination with an inhaled corticosteroid and anticholinergic significantly reduces the likelihood of severe asthma outcomes.

Trelegy Ellipta contains three active ingredients that work together to help improve breathing:

• Fluticasone furoate:
  • This is an inhaled corticosteroid (ICS).
  • It works by reducing inflammation in the lungs.
• Umeclidinium:
  • This is a long-acting muscarinic antagonist (LAMA), also known as an anticholinergic.
  • It works by relaxing the muscles around the airways, which helps to open them up.
• Vilanterol:
  • This is a long-acting beta2-adrenergic agonist (LABA).
  • It also works by relaxing the muscles around the airways, providing further bronchodilation.

This triple action helps to improve lung function, reduce symptoms such as shortness of breath and coughing, and enhance overall respiratory health.

Read the step-by-step instructions for using this medication in the container. Do not use Trelegy Ellipta unless your healthcare provider has taught you how to use the inhaler and understand how to use it correctly. You can also call Insulin Outlet and speak to one of our friendly pharmacists.

Here’s a helpful step-by-step guide on how to use a Trelegy Ellipta inhaler:

1. Open the outer tray and discard the desiccant.
2. Slide the cover down until you hear a “click.” This prepares the dose. The counter will decrease by one.
3. Hold the inhaler away from your mouth and breathe out completely. Do not breathe into the mouthpiece.
4. Place the mouthpiece between your lips and close your lips firmly around it.
5. Take one long, steady, deep breath through your mouth. Do not block the air vent with your fingers.
6. Remove the inhaler from your mouth and hold your breath for 3 to 4 seconds or as long as comfortable.
7. Breathe out slowly and gently, away from the inhaler.
8. Slide the cover-up and over the mouthpiece as far as it will go.
9. Rinse your mouth with water and spit it out. Do not swallow the water.

Use Trelegy Ellipta at the same time each day.

Do not stop using Trelegy Ellipta unless told to do so by your healthcare provider because your symptoms might worsen. Your doctor will change your medicines as needed.

‼️Keep a fast-acting inhaler readily available for immediate symptom relief. If you lack a rescue inhaler, promptly contact your healthcare provider for a prescription. Seek immediate medical attention if your breathing deteriorates, your rescue inhaler use increases, or your symptoms persist despite using it.

Trelegy Ellipta comes in 2 different strengths:

• 0.1mg/0.0625mg/0.025mg
  • This strength contains 100 micrograms (mcg) of fluticasone furoate, 62.5 mcg of umeclidinium, and 25 mcg of vilanterol per dose.
• 0.2mg/0.0625mg/0.025mg
  • This strength contains 200 mcg of fluticasone furoate, 62.5 mcg of umeclidinium, and 25 mcg of vilanterol per dose.

Your healthcare provider prescribed the strength that is best for you. Use this medication exactly as your healthcare provider tells you to use it.

If you miss a dose of Trelegy Ellipta, take it as soon as you remember. Do not take more than one inhalation per day. Take your following amount at your usual time.

If you take too much Trelegy Ellipta, call your healthcare provider or go to the nearest hospital emergency room right away if you have any unusual symptoms, such as worsening shortness of breath, chest pain, increased heart rate, or shakiness.

• Trelegy Ellipta can increase the risk of asthma-related deaths and should only be used in patients not adequately controlled on long-term asthma control medication.
• The medication may also cause serious cardiovascular events and should be used with caution in patients with cardiovascular disease. Regular monitoring of lung function and cardiovascular status is recommended.
• Long-acting beta2-adrenergic agonists (LABA) as monotherapy (without ICS) for asthma are associated with an increased risk of asthma-related death.
• Available data from controlled clinical trials also suggest that using LABA as monotherapy increases the risk of asthma-related hospitalization in pediatric and adolescent patients.
• These findings are considered a class effect of LABA monotherapy. When LABA is used in fixed-dose combination with ICS, data from large clinical trials do not show a significant increase in the risk of serious asthma-related events (hospitalizations, intubations, death) compared with ICS alone.
• Should not be initiated in patients during rapidly deteriorating or potentially life-threatening episodes of COPD or asthma. Trelegy Ellipta has not been studied in subjects with acutely deteriorating COPD or asthma. The initiation of Trelegy Ellipta in this setting is not appropriate.
• Lower respiratory tract infections, including pneumonia, have been reported following the inhaled administration of corticosteroids.
• Trelegy Ellipta should not be used in children younger than 18 years of age. It is unknown if Trelegy Ellipta is safe and effective in children younger than 18.

It’s important to be aware of the potential side effects of Trelegy Ellipta. Here’s a breakdown of common and serious side effects, along with some guidance:

Common Side Effects:

• Headache
• Upper respiratory tract infections (such as common cold, sore throat, runny nose)
• Oral thrush (a fungal infection in the mouth or throat)
• Cough
• Back pain
• Joint pain

Serious Side Effects:

• Pneumonia (especially in people with COPD)
• Weakened immune system (increased risk of infections)
• Reduced adrenal function (adrenal insufficiency)
• Sudden breathing problems (bronchospasm)
• Serious allergic reactions (rash, hives, swelling, difficulty breathing)
• Heart problems (increased blood pressure, fast or irregular heartbeat)
• Eye problems (glaucoma, cataracts, blurred vision)
• Changes in laboratory blood values (high blood sugar, low potassium)
• Urinary retention
• Osteoporosis1

Rinsing your mouth with water after each use can help prevent oral thrush.

If you experience mild side effects like headaches or coughs, they may subside as your body adjusts to the medication.

Trelegy Ellipta and certain other medicines may interact with each other. This may cause serious side effects. Especially tell your healthcare provider if you take:

• anticholinergics (including tiotropium, ipratropium, aclidinium),
• atropine,
• other LABA (including salmeterol, formoterol, arformoterol, olodaterol, and indacaterol),
• antifungal
• anti-HIV medicines.

Do not use other medicines that contain a LABA or an anticholinergic for any reason. Ask your healthcare provider or pharmacist if any of your other medicines are LABA or anticholinergic medication.

• Store at room temperature away from light, heat, and moisture. Store away from the bathroom.
• Wait until you are ready to use the newly acquired inhaler before opening the sealed tray.
• The inhaler should be thrown out 6 weeks after first removing it from the tray or when the dose counter reads zero.
• Keep all medications out of the reach of children and pets.
• If instructed, do not flush medications down the toilet or pour them down the drain. You should properly dispose of this product once it has reached the end of its shelf life. Get in touch with your local pharmacy or local waste disposal company for more information.

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