Wegovy (Semaglutide) Injection

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Wegovy (semaglutide) is prescribed to patients with weight management goals in mind.

It’s a once-weekly injectable medication specifically approved for use in adults with:

• obesity (body mass index [BMI] of 30 or greater)
• or overweight (BMI of 27 or greater)

who also have at least one health issue linked to excess weight, like high blood pressure, type 2 diabetes, or elevated cholesterol.

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This medication is prescribed for:

• Weight loss and long-term weight management.
• Supporting healthier metabolic function.
• Helping patients with obesity-related conditions like type 2 diabetes, high blood pressure, or high cholesterol.

By acting as a GLP-1 receptor agonist, Wegovy helps regulate blood sugar levels and other metabolic processes. This can contribute to improvements in overall metabolic health and in consequence, to sustainable weight loss.1

Wegovy is a glucagon-like peptide-1 (GLP-1) receptor agonist. This means it mimics a natural hormone in your body that helps regulate appetite, food intake, and blood sugar levels.

By activating GLP-1 receptors in the brain, it can increase feelings of fullness and reduce hunger, leading to decreased calorie intake and subsequent weight loss.

Wegovy is usually administered in weekly injections. However, you should always follow your doctor’s administering schedule.

Also, it’s important to learn how to inject Wegovy properly. If you don’t know how to administer the medication, ask your doctor or pharmacist to show you.

General Steps (Always refer to your specific instructions):

1. Preparation:

• Wash your hands thoroughly.
• Gather your Wegovy pen, a new needle, and alcohol wipes.
• Check the medication for clarity and expiration date.

2. Needle Attachment:

• Put a new needle on the pen, following the provided directions.
• Remove the needle cap.

3. Injection:

• Clean the injection site with an alcohol wipe.
• Pinch the skin at the injection site.
• Insert the needle at a 90-degree angle.
• Press and hold the injection button until the full dose is administered.
• Hold the needle in the skin for the recommended time, as per the instructions, before removing it.

4. Disposal:

• Safely dispose of the used needle and pen in an FDA-cleared sharps disposal container.

Wegovy is administered as a subcutaneous injection once a week.

It can be taken at any time of day, with or without meals.

It’s recommended to take it on the same day each week.

You can inject Wegovy in your stomach, thigh, or upper arm.

To avoid skin irritation, use a different injection spot each week.

Wegovy is supplied in a convenient, pre-filled pen.

Each pen is designed for single use.

It is very important to use a new needle with each injection.

Wegovy is available in the following dose strengths:

• 0.25 mg
• 0.5 mg
• 1 mg
• 1.7 mg
• 2.4 mg

Wegovy Dose Escalation Schedule:

The typical Wegovy dosing schedule involves gradually increasing the dose over several weeks to minimize potential side effects. Here’s a general outline:

• Weeks 1-4: 0.25 mg once weekly
• Weeks 5-8: 0.5 mg once weekly
• Weeks 9-12: 1 mg once weekly
• Weeks 13-16: 1.7 mg once weekly
• Week 171 and onward: 2.4 mg once weekly (maintenance dose)

However, please note that your medical provider decides what dosage and administering schedule you should follow.

Your doctor may adjust the dosing schedule based on your individual response to the medication and any potential side effects you may experience.

There are certain considerations to take into account when administering or planning to begin treatment with Wegovy.

• Thyroid tumor: Wegovy carries a potential risk of thyroid C-cell tumors, including MTC. It’s contraindicated for individuals with a history of MTC or MEN 2. Thyroid tumor symptoms warrant prompt medical evaluation.
• Pancreatitis: Wegovy may also increase the risk of pancreatitis. Patients should be aware of symptoms like severe abdominal pain, nausea, and vomiting and seek immediate medical attention if they occur.
• Gallbladder Problems: Gallbladder problems can also occur. Rapid weight loss, which can occur with Wegovy, is a known risk factor for gallstone formation.
• Hypoglycemia: Wegovy can increase the risk of hypoglycemia (low blood sugar), especially in patients with type 2 diabetes who are also taking other diabetes medications like insulin or sulfonylureas. It’s crucial for these patients to monitor their blood sugar levels closely and be aware of hypoglycemia symptoms.
• Kidney Problems: Wegovy can indirectly affect kidney function. Gastrointestinal side effects like nausea, vomiting, and diarrhea can lead to dehydration, which can worsen existing kidney problems. Patients with kidney disease should be closely monitored.
• Increased Heart Rate: Wegovy has been associated with an increase in resting heart rate. Patients should report any persistent or concerning heart palpitations or rapid heart rate to their healthcare provider.
• Depression: There have been reports of mental health side effects, including depression and suicidal ideation, with GLP-1 receptor agonists. It’s vital for patients to be aware of potential mood changes and to report any concerns to their healthcare provider.

Wegovy, while effective for weight management, can cause a range of side effects. It’s important to be aware of both common and serious potential risks.

Common Side Effects:

• Nausea
• Vomiting
• Diarrhea
• Constipation
• Abdominal pain
• Headache
• Fatigue
• Upset stomach
• Dizziness
• Bloating

Serious Side Effects:

• Pancreatitis
• Gallbladder problems
• Hypoglycemia (low blood sugar)
• Kidney problems (kidney failure)
• Increased heart rate
• Serious allergic reactions
• Depression or suicidal thoughts
• Thyroid C-cell tumors

It’s crucial to communicate any side effects you experience to your healthcare provider.

They offer guidance on managing side effects and can assess the need for treatment modifications.

There are also certain drug interactions you should be aware of when taking Wegovy. Some of these medications include:

• Other weight loss medications – May increase gastrointestinal discomfort.
• Diabetes medications (insulin, sulfonylureas) – Increase risk of low blood sugar.
• Blood pressure and diuretic medications – May lead to dehydration.
• Oral medications – Absorption may be delayed due to slowed digestion.