Repatha Auto Injector (Evolocumab)

Repatha can cause serious allergic reactions, including hypersensitivity reactions such as angioedema and urticaria. Patients should be monitored for signs of allergic reactions, and treatment should be discontinued if any severe hypersensitivity reactions occur. Regular follow-up is necessary to assess the effectiveness and safety of the medication.

If you are allergic to Evolocumab or its ingredients, do not take Repatha. If you have or have had any liver disease, inform your physician before starting the treatment. Seek medical attention if you experience angioedema or symptoms of an allergic reaction. Immediately notify your healthcare provider, and your doctor will monitor you until your symptoms improve. This medicine has not been studied in children under ten years of age. If you are planning to get pregnant or think you may be pregnant, please inform your doctor.

There may be redness, pain, or bruising at the injection site. Tell your doctor or immediately contact us and we can set you up with a pharmacists consultation, if any of these effects persist or worsen.

You have been prescribed this medication based on your doctor’s judgment that the benefit to you outweighs the risk of side effects. There are a few severe side effects associated with this medication.

It is rare for this drug to cause a severe allergic reaction. In the event of severe allergic reactions, such as rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, or difficulty breathing, seek medical attention right away.

There may be other side effects not listed here. Contact your doctor or pharmacist if you notice other effects not listed above.

Consult your doctor if you are experiencing side effects in the United States—report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

It is possible that Repatha could raise blood sugar levels to the point where diabetes develops. Repatha was studied in a large clinical trial involving 27,525 people with heart disease. When the study began, some of the participants did not have diabetes.

The group that did not have diabetes at the beginning of the study:

● Diabetes developed in 8.1% of people taking Repatha

●  People who took a placebo developed diabetes in 7.7% of cases

Symptoms of diabetes include fatigue, thirst, dry mouth, and frequent urination.

Consult your doctor if you experience symptoms of diabetes.

If you suspect poisoning, call 1-800-222-1222 or seek emergency medical attention.

There are no known interactions between Repatha and supplements, foods, vaccines, or lab tests.

Consult your doctor or contact us, and we will connect you with one of our pharmacists before using Repatha if you take supplements, herbs, or vitamins. You can avoid potential interactions by sharing this information with them.

Talk to your doctor or pharmacist if you have questions about interactions.

Repatha has yet to be reported to interact with food at this time. Talk to your doctor if you have questions about eating certain foods while taking Repatha.

Repatha has not been reported to interact with vaccines or lab tests. During your Repatha treatment, talk to your doctor if you have any questions about vaccines or lab tests.

Repatha does not interact with cannabis (commonly called marijuana) or cannabis products such as cannabidiol (CBD). Before using cannabis with Repatha, talk to your doctor.

Despite being illegal at the federal level, cannabis is legal in many states to varying degrees.

Follow your doctor’s instructions exactly when using this medicine. If you’re not sure, talk to your doctor.

Depending on the underlying condition, a different dose is recommended:

● Adults with primary hypercholesterolemia and mixed dyslipidemia should take 140 mg every two weeks or 420 mg monthly.

● Children aged ten years or older with heterozygous familial hypercholesterolemia should receive 140 mg every two weeks or 420 mg once a month.

● A starting dose of 420 mg once a month is recommended for adults and children aged ten years or older with homozygous familial hypercholesterolemia. Your doctor may increase the amount after 12 weeks to 420 mg every two weeks. A doctor may decide to start you on 420 mg every two weeks if you also undergo apheresis, a procedure similar to dialysis that removes cholesterol and other fats from the blood.

● Adults with established atherosclerotic cardiovascular disease (a history of heart attack, stroke, or blood vessel problems) should take 140 mg every two weeks or 420 mg once a month.

Repatha is injected under the skin (subcutaneous).

Pre-filled pens contain only 140 mg of medicine per pen, so if your doctor prescribes 420 mg, you must use three pre-filled pens. All injections should be given within 30 minutes of reaching room temperature.

You or your caregiver must receive training on how to prepare and inject Repatha correctly if your doctor decides that you or your caregiver can give Repatha injections. It would be best not to inject Repatha until your doctor or nurse shows you how.

Use the missed dose within 7 days of the injection’s due date. If you are more than seven days late for the injection, skip the missed dose. If you miss a dose, go back to your original schedule and take the medicine again when your next scheduled dose is due.

To make up for a missed dose, do not take extra medicine.

If you suspect poisoning, call 1-800-222-1222 or seek emergency medical attention.

Children should not be allowed to see or touch this medicine.

Do not use the medicine if the expiration date on the label or carton has passed. Expiration dates refer to the last day of the month.

Store in the refrigerator (2°C – 8°C). Keep out of the freezer.

Protect from light by storing it in the original carton.

Before injection, let your prefilled pen reach room temperature (up to 25°C) outside the refrigerator. As a result, the injection will be more comfortable. Repatha should be stored at room temperature (up to 25°C) for one month after removal from the refrigerator.

This medicine should not be used if it is discolored or contains large lumps, flakes, or colored particles.
Wastewater and household waste should not be used to dispose of medicines.

If you no longer need any medicines, ask your pharmacist how to dispose of them. As a result of these measures, the environment will be protected.

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