With global air pollution increasing annually, the risk of respiratory diseases has risen sharply in recent times. Today an estimated 545 million people have asthma and other chronic respiratory diseases in the world and need prescription drugs.
Respiratory diseases like asthma affect patients by constricting the airways in the lungs; this happens due to the buildup of mucus in the airways or inflammation in the muscle lining of the bronchial tubes. This leads to difficulty breathing and feelings of suffocation in the patient. If not treated in time, such diseases can worsen and even cause death.
With so much of the world having respiratory diseases and 14% of the children globally having asthma, pharmaceutical companies are trying to find newer and better solutions for the condition.
A new class of drugs called bronchodilator combinations is found to be effective at treating asthma and other respiratory diseases and stopping such conditions from worsening. Two such bronchodilator combinations are Trelegy and Symbicort, which work as long-term treatments for asthma symptoms and other respiratory problems and give patients a chance to improve their quality of life.
And what does the Symbicort vs. Trelegy comparison look like? Which one is better? Let’s analyze it!
Bronchodilator Combinations
Bronchodilators are a type of medication that helps to ease breathing problems by relaxing the lungs in the airways and opening the bronchi (airways). They are generally used for long-term treatment in patients whose airways are chronically constricted.
Bronchodilator combinations are a class of medication that is used for the treatment of diseases that affect breathing and lung function.
Bronchodilator combinations are generally available in the form of inhalers and inhalation devices. They either contain more than one bronchodilator or one bronchodilator and one steroid.
Some bronchodilator combinations that contain more than one bronchodilator are typically composed of one long acting and one short acting bronchodilator also to provide quick relief.
Bronchodilator combinations with steroids work as a preventative measure that works by inhibiting the body’s inflammatory response, which helps in alleviating symptoms of asthma and other chronic respiratory diseases while also improving lung function.
What is Trelegy?
Trelegy (or Trelegy Ellipta, to be exact) is a medicine used to treat asthma and chronic obstructive pulmonary disease (COPD). The medication is administered through a dedicated inhaler. Trelegy Ellipta’s active drugs are fluticasone and umeclidinium, the former being an anti-inflammatory steroid while the latter being a long-acting anticholinergic bronchodilator, both amazingly helpful in easing asthma and COPD symptoms.
Fluticasone helps to open up the bronchial tubes by decreasing the inflammation, because of which the airways are constricted, while umeclidinium blocks the nerve reflex that causes the airways to constrict back.
Trelegy should not be used as a rescue inhaler during sudden trouble breathing due to a bronchospasm or asthma attack, as it is not a quick fix. Instead, Trelegy Ellipta works as a long-acting medication that prevents against having a severe lung infection or other complications.
So, taking Trelegy Ellipta only when your chest is feeling tight will not do you any good, but taking it every day for more extended maintenance treatment will prevent it altogether.
Many Americans have been purchasing a Trelegy Ellipta inhaler from Canada, as many health coverage programs do not provide coverage for this medication.
Dosage – Trelegy Ellipta
Trelegy Ellipta comes in the form of an inhaler, and each inhaler contains 30 doses. Each inhaler contains two foil strips with a medication in each.
One strip holds 100mcg or 200mcg of fluticasone, while the other holds 62.5mcg of umeclidinium and 25mcg of vilanterol.
Trelegy should only be taken once a day, and the maximum recommended dose for the drug is also one puff per day. Exceeding the recommended dose puts you at the risk of severe side effects.
Note: It is important to rinse your mouth after inhaling a dose. This helps prevent oral infections.
Side Effects – Trelegy Ellipta
As with any other medications, there are some side effects that a person may experience during the Trelegy Ellipta treatment. These side effects can either be mild or severe.
Mild Side Effects of Trelegy
- Mouth and throat irritation
- Change in the sense of taste
- Bronchitis
- Stomachache
- Flu
- Upper respiratory infection (common cold)
- Sinus infection
- Headache
- Diarrhea
- Back pain and joint pain
Serious Side Effects of Trelegy
- Pneumonia
- Decreased adrenal gland function
- Thrush (fungal infection) in the mouth or throat
- Weakened immune system
- Increased blood sugar levels
- Decreased levels of potassium in the blood
- Bronchospasm
- Changes in heart rate or blood pressure
- Weakened bones
- Nervous system problems
- Eye problems such as glaucoma or cataracts
What Is Symbicort?
Symbicort is a medication used to treat and control symptoms of Chronic Obstructive Pulmonary Disease (COPD), asthma, and other breathing-related diseases. The medication is administered through an inhaler and contains a combination of two active ingredients – Budesonide and Formoterol, the former being a steroid that lessens inflammation while the latter being a long-acting bronchodilator.
Budesonide works by preventing inflammation in the airways, making asthma attacks less severe. In contrast, Formoterol works by helping the muscles around your airways stay relaxed so that they may not constrict again.
Symbicort should not be used as a rescue inhaler during asthma or bronchospasm attacks, as it will not do you any good. Instead, it should be used for long-term asthma treatments to control it and prevent it from getting out of hand.
Dosage – Symbicort
Symbicort comes in the form of a metered-dose inhaler. Each inhaler consists of either 60 or 120 puffs. Each oral inhalation of the medication is a premeasured puff and is available in two metered dosages: 80mcg/4.5mcg per puff and 160mcg/4.5mcg per puff.
Only two puffs of Symbicort should be taken daily by asthma and COPD patients. The maximum dosage to treat COPD patients is 4 puffs a day (Symbicort 160mcg), and the maximum dosage for asthma patients is 12 puffs a day (Symbicort 80mcg).
Exceeding the recommended maximum dosage puts you at an increased risk of experiencing severe side effects.
Note: It is important to rinse your mouth after inhaling a dose. This helps prevent oral infections.
Side Effects – Symbicort
As with any medication, there are many side effects that a person may experience when taking Symbicort. These side effects can either be mild or severe.
Mild Side Effects
These are very common to experience and often go away within a few days of using the drugs. They may include:
- Pain when speaking and trouble speaking
- Back pain
- Headache
- Nausea or vomiting
- Upper respiratory tract infection, such as the common cold, flu, bronchitis, or sinusitis
- Nasal congestion
- Stomach discomfort
- Oral thrush (a yeast infection in your mouth)
Serious Side Effects
These aren’t that common to experience, but there is a possibility of it happening. They can include:
- Serious asthma-related events
- Nervous system problems
- Decreased growth in children
- Decrease in bone density
- Pneumonia
- Cardiovascular problems
- Bronchospasm
- Increased cortisol levels and decreased function of the adrenal glands
- High blood sugar level
- Increased risk of infection
- Eosinophilia (high level of certain white blood cells)
- Low levels of potassium in the blood
Trelegy Ellipta
$155.27 – $184.95Trelegy vs. Symbicort – Which One Is Better?
There was a Trelegy vs. Symbicort study comparing them over the course of 24 weeks, where standard doses of each medication were given to patients suffering from respiratory diseases, such as asthma and COPD.
A questionnaire designed to measure overall health, daily life, and perceived well-being in patients with obstructive airway disease, known as St. George’s Respiratory Questionnaire (SGRQ), showed that 50% of patients taking Trelegy Ellipta responded to the survey and reported life improvement, compared to 41% of the patients taking Symbicort.
Patients taking Trelegy also showed significantly improved lung function compared to patients taking Symbicort.
The study also showed that COPD patients who were treated with Trelegy showed a 35% decrease in exacerbations and also had to be hospitalized less often compared to patients treated with Symbicort.
Symbicort vs. Trelegy Comparison – Verdict
Trelegy is by far the best lung drug on the market to treat severe respiratory diseases like COPD and asthma. Unlike other inhaler medications that have to be taken multiple times a day, Trelegy only has to be inhaled once a day. Trelegy is the only Bronchodilator combination inhaler on the market to mix three active drugs, unlike other Bronchodilator combinations that combine two.
The medication has also been shown to be ahead of all the available lung-related drugs in results and effectiveness, according to a recently conducted study.
Because Trelegy Ellipta is a breakthrough medicine compared to typical Bronchodilator combinations, it doesn’t have any competition; this makes the drug far more expensive than any other drugs for respiratory problems available on the present market.
The availability of Trelegy Ellipta does not lessen the potency of Symbicort, as the latter is still a very effective drug and is far cheaper and more accessible than Trelegy.
Only making a Trelegy vs. Symbicort comparison is when the latter falls short. Still, most people would be satisfied with using Symbicort for their long-term treatment, but if you have the budget for Trelegy, then it would be a good idea to invest in it.
If you have difficulties getting Trelegy Ellipta, we are here to help you. Our experts will make it possible for you to have access to those inhalers from Canada at reasonable prices. Contact us now if you need help!
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